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Exploration of the Possible Relationships Between Gut and Hypothalamic Inflammation and Allopregnanolone: Preclinical Findings in a Post-Finasteride Rat Model

research Exploration of the Possible Relationships Between Gut and Hypothalamic Inflammation and Allopregnanolone: Preclinical Findings in a Post-Finasteride Rat Model.

July 2025 in “PubMed”

This preclinical study found that finasteride withdrawal in rats caused inflammation in the gut and hypothalamus, while allopregnanolone treatment partially reduced these effects, suggesting potential therapeutic benefits for post-finasteride syndrome.

research Pathways to inflammation: acne pathophysiology

68 citations , May 2011 in “European Journal of Dermatology”

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

research Stress-induced Interaction of Skin Immune Cells, Hormones, and Neurotransmitters

88 citations , May 2020 in “Clinical therapeutics”

This review discusses the role of stress mediators in skin diseases and reports no new clinical results; the authors suggest further research in skin psychoneuroimmunology.

research Neuroendocrine Perspectives in Alopecia Areata: Does Stress Play a Role?

69 citations , May 2009 in “Journal of Investigative Dermatology”

This research highlights that psychological stress can adversely affect hair growth in mice, implicating potential pathways that may be relevant in understanding stress-induced hair growth inhibition in humans.

research Bibliometric Study of Adaptogens in Dermatology: Pharmacophylogeny, Phytochemistry, and Pharmacological Mechanisms

1 citations , February 2023 in “Drug Design Development and Therapy”

This review discusses the dermatological effects and potential mechanisms of plant adaptogens, emphasizing their role in skin health and aging without presenting new experimental results.

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community How I recovered from 4+ years of severe balding ages 20-24 by dieting, lifestyle changes and ONLY using topical minoxidil

in Progress Pictures 473 upvotes 1 year ago

A user reversed severe hair loss with dieting, lifestyle changes, and topical minoxidil, highlighting reduced inflammation and body fat. The conversation debates finasteride's effectiveness and the impact of diet and lifestyle on hair health.

community There’s actually a quite good chance that next year, we might see a new treatment get FDA approval for the first time in nearly three decades.

78 upvotes 1 year ago

Breezula, a potential new hair loss treatment, may receive FDA approval soon, but it is expected to be a weaker alternative to finasteride and minoxidil. Concerns include its twice-daily application and possible side effects like HPA axis suppression.

community What makes them say exercise doesn't increase hair loss?

in Research/Science 45 upvotes 1 year ago

Exercise has minimal impact on hair loss, with weight lifting slightly increasing DHT and cardio potentially decreasing it. Finasteride and dutasteride are effective treatments for managing hair loss, even for those who exercise regularly.

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