February 2026 in “International Journal of Molecular Sciences” This review discusses the potential benefits of hyperthermia in cancer therapy, combined with natural compounds, to enhance treatment efficacy and reports no new clinical results.
July 2004 in “Journal of Clinical Oncology” This study found that therapeutic isolated limb perfusion with melphalan for in-transit melanoma metastases resulted in a high response rate but was associated with some systemic toxicity, including nausea, vomiting, and transient bone marrow depression.
July 2004 in “Journal of Clinical Oncology” This study found therapeutic isolated limb perfusion with melphalan to be effective for in-transit melanoma metastases on a limb, with a high response rate and transient systemic toxicity.
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June 1982 in “The BMJ” Cooling the scalp below 22°C before and during chemotherapy can help prevent hair loss.
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October 2017 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This literature review reported that scalp hypothermia significantly decreases the occurrence of chemotherapy-induced alopecia, increasing effectiveness by 2.7-fold in controlled clinical trials and 3.9-fold in randomized trials, and highlighted a need for standard guidelines for its use.