15 citations
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May 1986 in “Journal of the American Veterinary Medical Association” In this study, a dog with alopecia and a Sertoli cell tumor showed hyperprogesteronemia, and its hair regrew after castration, with progesterone levels reducing toward normal.
November 2014 in “Clinical Neurophysiology” High doses of progesterone can reduce seizures in mice.
26 citations
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November 2013 in “Neuroscience” This study suggests that progesterone has both THP/GABAA-dependent and independent anticonvulsive effects in a hippocampal-kindled mouse model.
June 2014 in “Belarusian State Pedagogical University repository (Belarusian State Pedagogical University)” In this study, progesterone showed anticonvulsant effects in mice via a mechanism that is at least partially independent of its metabolism to THP, without significant psychotoxicity.
This study suggests that 5alpha-dihydroprogesterone could be an effective, non-sedative anticonvulsant for drug-resistant complex partial seizures, as observed in a rat model.