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research Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation

54 citations , December 2011 in “American Journal Of Pathology”

This study found that immune-mediated destruction of bulge stem cells is a key factor in the alopecia observed in AE mice, suggesting it as a model for studying primary cicatricial alopecias, particularly lichen planopilaris.

research Vitamin D receptor ablation alters skin architecture and homeostasis of dendritic epidermal T cells

16 citations , February 2005 in “British journal of dermatology/British journal of dermatology, Supplement”

This study found that VDR deficiency in mice leads to various skin pathologies but does not affect the phenotype or function of Langerhans cells.

Cryo-EM and Molecular Dynamics of TRPV3 Channel in Activated State Reveal Structural Features Implicated in Severe Itch and Hyperkeratosis

research 738 Cryo-EM and molecular dynamics of TRPV3 channel in activated state reveal structural features implicated in severe itch and hyperkeratosis

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that structural changes in the TRPV3 channel are linked to severe skin conditions like Olmsted syndrome, with differences observed between heat-activated and resting states.

research Keratins: Dynamic, flexible structural proteins of epithelial cells

13 citations , May 2001 in “Current problems in dermatology”

Keratin proteins in epithelial cells are dynamic and crucial for cell processes and disease understanding.

research TCDD-induced activation of aryl hydrocarbon receptor regulates the skin stem cell population

9 citations , January 2015 in “Medical hypotheses”

This report suggests that TCDD may alter human epidermal stem cell populations by upregulating c-Myc, potentially leading to increased stem cell turnover during chloracne development.

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community DHT Harms Scalp Microbiome: DHT Itch is REAL

413 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

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learn Alpha Keratin

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