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Natural Product-Inspired Bis(Trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

research Natural Product-Inspired Bis(Trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

August 2025 in “ACS Omega”

New compounds show promise as nonsteroidal treatments for hair loss.

research Natural Product-Inspired Bis(Trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

August 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

Certain hydroxycinnamate derivatives may effectively inhibit enzymes linked to hair loss with low toxicity.

research Novel Cosmeceuticals from Plants: An Industry-Guided Review

39 citations , June 2017 in “Journal of Applied Research on Medicinal and Aromatic Plants”

Plant-based ingredients are effective and safe for modern skincare products.

research Potential Health Benefits of Dates Based on Human Intervention Studies: A Brief Overview

3 citations , March 2022 in “Haya: the Saudi journal of life sciences”

Dates may improve heart health, fight infections, protect kidneys, reduce inflammation, support pregnancy, promote dental and bone health, enhance mental function, and have anti-cancer properties, and are also beneficial for skin and hair care.

research Advances and Challenges in Plant Sterol Research: Fundamentals, Analysis, Applications and Production

1 citations , September 2023 in “Molecules (Basel. Online)”

Plant sterols have health benefits like lowering cholesterol, but more research is needed to understand their effects and improve their extraction and sustainability.

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community Possible natural pp405 solution

in Research/Science 45 upvotes 3 months ago

Rotenone, a natural plant extract, may promote hair growth by increasing LDH activity and blocking MPC in the scalp, but it carries risks due to its toxicity. The suggested formulation includes Barbasco extract, DMSO, propylene glycol or PEG-400, ethanol, and a carrier oil.