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Hydrolyzed Collagen

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Complete Defect in PA-PLA1α Secretion Function Leading to Autosomal Recessive Woolly Hair and Hypotrichosis: Insights from a Novel Compound Heterozygous LIPH Variant Study in a Chinese Pedigree

research Complete Defect in PA-PLA1α Secretion Function Leading to Autosomal Recessive Woolly Hair and Hypotrichosis: Insights from a Novel Compound Heterozygous LIPH Variant Study in a Chinese Pedigree

May 2025 in “Frontiers in Genetics”

A new genetic variant in the LIPH gene causes hair growth issues in a Chinese patient.

research A Monoallelic Two-Hit Mechanism in PLCD1 Explains the Genetic Pathogenesis of Hereditary Trichilemmal Cyst Formation

21 citations, October 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

A specific gene change plus an additional mutation in the same gene cause hereditary trichilemmal cysts.

research The β9 Loop Domain of PA-PLA1α Has a Crucial Role in Autosomal Recessive Woolly Hair/Hypotrichosis

11 citations, April 2012 in “Journal of Investigative Dermatology”

A specific mutation in PA-PLA1α causes abnormal hair growth.

research The Function and Structure of the Skin

4 citations, November 2014

The skin protects the body, regulates temperature, senses touch, and makes vitamin D.

research Phosphatidylinositol-Specific Phospholipase C2 Functions in Auxin-Modulated Root Development

28 citations, December 2018 in “Plant, cell & environment/Plant, cell and environment”

A protein called PLC2 is important for the growth and development of plant roots influenced by auxin.

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community Minoxidil Sulfate makes everyone a responder

in Research/Science 262 upvotes 6 months ago

Minoxidil sulfate is more effective than regular minoxidil, especially for those with low sulfotransferase levels or scalp sensitivity, but it is unstable unless delivered in a liposomal format. Combining minoxidil with tretinoin can enhance effectiveness, and stopping minoxidil use can lead to rapid hair loss.

community RU-58841 Lung Disease Possibility | Chest pain, "heart issues", etc

in Treatment 24 upvotes 1 year ago

Some users of RU-58841 report cardiovascular symptoms like heart palpitations and chest tightness, which may be linked to its metabolites causing lung disease. The safety of RU-58841 is uncertain due to lack of long-term data and concerns about product purity, especially from gray market sources.