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IL-9 Mediated Human Primary Keratinocytes Invasion Is Dependent on MLC Controlled Contractility and Independent of MMP Activity

research 879 IL-9 mediated human primary keratinocytes invasion is dependent on MLC controlled contractility and independent of MMP activity

April 2018 in “Journal of Investigative Dermatology”

This study found that IL-9 influences the behavior of human primary keratinocytes by promoting motility while reducing invasion potential through a novel mechanism independent of matrix-metalloproteinases.

Generation of Human Hair Follicle Organoids In Vitro and Ex Vivo by Co-Culture of Primary Human Hair Matrix Keratinocytes and Dermal Papilla Fibroblasts

research 773 Generation of human hair follicle organoids in vitro and ex vivo by co-culture of primary human hair matrix keratinocytes and dermal papilla fibroblasts

June 2020 in “Journal of Investigative Dermatology”

This study observed that human primary adult hair matrix keratinocytes may have the potential to generate hair follicle organoids, suggesting possible applications in hair follicle neogenesis and preclinical hair growth agent screening.

research Use of primary keratinocyte cultures from plucked human hairs for analysis of gap junctional intercellular communication

3 citations , January 1991 in “Toxicology in Vitro”

This study reports that hair follicle cultures are effective for gap junctional intercellular communication studies and can be used to assess the tumor-promoting activity of certain environmental chemicals.

DermaCult Keratinocyte Expansion Medium: A Serum- and BPE-Free Medium Supporting Long-Term Feeder-Free Expansion of Primary Human Epidermal and Pluripotent Stem Cell-Derived Keratinocytes

research 566 DermaCult™ Keratinocyte Expansion Medium, a Serum- and BPE-free Medium Supporting Long-term Feeder-free Expansion of Primary Human Epidermal and Pluripotent Stem Cell-Derived Keratinocytes

November 2022 in “Journal of Investigative Dermatology”

This study found that DermaCult™ Keratinocyte Expansion Medium allows for significantly extended growth of human epidermal keratinocytes while maintaining their differentiation potential.

research Safe Selection of Genetically Manipulated Human Primary Keratinocytes with Very High Growth Potential Using CD24

25 citations , August 2007 in “Molecular Therapy”

This study found that using ectopic expression of CD24 is a promising approach for selecting genetically modified human epidermal stem cells for safe cutaneous gene therapy in cancer-prone conditions.

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Community Join

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community DIY treatment... Shedding completely stopped after 1.5 yrs

251 upvotes 4 years ago

Vitamin C mixed with shampoo stopped shedding and promoted hair regrowth after 1.5 years. Both the person and their wife experienced significant hair loss reduction with this method.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

103 upvotes 4 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community New and Interesting HairLoss Studies/Papers/Reviews

44 upvotes 6 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

133 upvotes 2 years ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community Other factors involved then DHT/5aR

5 upvotes 3 months ago

DHT is the primary cause of hair loss, but factors like diet, stress, and lifestyle can influence its severity. Treatments like finasteride and dutasteride target DHT, while maintaining overall health is also important.

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Learn

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learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

learn Stem Cell Factor

learn Epidermal Growth Factor

learn Thymosin Beta 4

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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