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Generation of an Integration-Free Human Induced Pluripotent Stem Cell Line MUSIi010-A from Occipital Scalp Fibroblasts of a Male Patient with Androgenetic Alopecia

research Generation of an integration-free human induced pluripotent stem cell line MUSIi010-A from occipital scalp fibroblasts of a male patient with androgenetic alopecia

June 2019 in “Stem Cell Research”

This study established a pluripotent stem cell line from a patient with androgenetic alopecia, which can potentially be used to study the disease's pathological mechanisms.

research Multimodal Human Scalp Atlas Defines Cell Landscape and Lineage Architecture In Situ

June 2026 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study developed a comprehensive atlas of human scalp tissue to uncover cell states and lineages in hair follicles, identifying disease-specific cellular changes associated with non-scarring and scarring hair loss, which may offer new diagnostic and therapeutic insights.

A Multi-Omic Single-Cell Landscape of Perinatal Mouse Skin Maps Lineage Specification and Reveals Shared Dynamics in Human Fetal Skin

research A multi-omic single-cell landscape of perinatal mouse skin maps lineage specification and reveals shared dynamics in human fetal skin

April 2026 in “Experimental & Molecular Medicine”

This study used integrated single-cell chromatin and transcriptomic analyses in developing mouse skin to uncover gene networks involved in skin lineage specification and identified Mef2c+ upper fibroblasts as potential precursors to certain muscle-like structures, with cross-species findings in human skin.

research Lineage Identity and Location within the Dermis Determine the Function of Papillary and Reticular Fibroblasts in Human Skin

159 citations , September 2018 in “Journal of Investigative Dermatology”

This study identified two cell surface markers, FAP and CD90, that distinguish between papillary and reticular fibroblasts in human skin, suggesting distinct functions and distribution in dermal layers.

research The in vitro properties of dermal papilla cell lines established from human hair follicles

106 citations , April 1986 in “British Journal of Dermatology”

This study found that dermal papilla cells from human hair follicles form multi-layered aggregates when cultured in vitro, contrasting with the monolayer growth of dermal fibroblasts.

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community This is the best time in human history to be fighting hair loss

195 upvotes 4 years ago

This conversation discusses the advancements in treatments for hair loss, including finasteride, dutasteride, minoxidil and new promising treatments such as pyrilutamide and verteporfin. Other treatments discussed were taking minoxidil orally, tretinoin to turn non-responders into responders and microneedling to further boost growth.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community New Hair Loss Cure: AMP-303 Is Back. It’s what PP405 should have been.

7 upvotes 5 months ago

AMP-303 and AMP-601 are new hair loss treatments targeting dermal papilla cells, with AMP-303 showing early efficacy in transitioning vellus hairs to terminal hairs after one injection. Further clinical trials are planned, and these treatments are seen as promising due to their biologic approach and less frequent application compared to daily treatments.

community Microneedling with Verteporfin

3 upvotes 4 years ago

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

737 upvotes 3 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Vascular Endothelial Growth Factor

learn Beta Polypeptide

learn Epidermal Growth Factor

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