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Physiopathological Role of the Enzymatic Complex 5α-Reductase and 3α/β-Hydroxysteroid Oxidoreductase in the Generation of Progesterone and Testosterone Neuroactive Metabolites

research Physiopathological Role of the Enzymatic Complex 5α-Reductase and 3α/β-Hydroxysteroid Oxidoreductase in the Generation of Progesterone and Testosterone Neuroactive Metabolites

18 citations , March 2020 in “Frontiers in Neuroendocrinology”

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

research Synthesis and Actions of 5α-Reduced Metabolites of Testosterone in the Nervous System

1 citations , December 2021 in “Androgens”

Testosterone and its metabolites affect brain functions and could help treat neurological disorders.

research Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients

58 citations , April 2017 in “The Journal of Steroid Biochemistry and Molecular Biology”

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

research New Steps Forward in the Neuroactive Steroid Field

31 citations , March 2015 in “The Journal of Steroid Biochemistry and Molecular Biology”

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

research Post-Finasteride Syndrome: An Emerging Clinical Problem

26 citations , December 2019 in “Neurobiology of Stress”

Post-finasteride syndrome causes lasting sexual, neurological, and physical side effects in some people after taking finasteride.

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community If I would have started earlier I would probably have quit

in Chat 117 upvotes 5 months ago

The conversation discusses hair loss treatments, including Avodart (Dutasteride), finasteride, minoxidil, and peptide serums with ingredients like Redensyl and Saw Palmetto. Users share experiences and opinions on the effectiveness and side effects of these treatments, with some skepticism about claims regarding DHT and its role in hair loss.