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research Modulation of Vitamin D Receptor Activity by the Corepressor Hairless: Differential Effects of Hairless Isoforms

18 citations , October 2009 in “Endocrinology”

Different Hairless isoforms affect Vitamin D receptor activity in hair regulation, with one repressing and the other stimulating it.

research Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer

28 citations , January 2012 in “Biological & pharmaceutical bulletin”

Hairless protein can both repress and activate vitamin D receptor functions, affecting gene regulation.

research Vitamin D Receptor-Mediated Control of Soggy, Wise, and Hairless Gene Expression in Keratinocytes

13 citations , November 2013 in “Journal of Endocrinology/Journal of endocrinology”

Vitamin D receptor helps control hair growth genes in skin cells.

research Molecular Evolution of HR, a Gene That Regulates the Postnatal Cycle of the Hair Follicle

9 citations , July 2011 in “Scientific Reports”

Changes in the HR gene have influenced hair growth and may lead to hair loss conditions in humans.

research Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity

25 citations , November 2018 in “Cell reports”

The study concluded that specific proteins are necessary to maintain the structure that holds epithelial cells tightly together.

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community This tells you if you're shedding or losing hair (along with other things like fibrosis)

in Research/Science 32 upvotes 8 months ago

High frequency ultrasonography and HR-MRI can help identify hair shedding causes like inflammation and fibrosis. The conversation discusses the potential of using these technologies to evaluate treatments like Verteporfin for hair regeneration.

community Have some questions about prescription I got from a trichologist

in Chat 1 upvotes 7 months ago

A trichologist prescribed Biotrade Sebomax HR Anti-Hair Loss Tonic, Spectral DNC-N Nanoxidil, Hairfollic Him/Man Vitamins, and Bosley MD DHT blocking supplements instead of finasteride due to potential risks at age 21. The user questions the legitimacy of the treatment and considers seeking a second opinion.

community A better treatment would be a localized 5ar inhibitor that breaks down when it enters blood or leaves hair follicle

in Chat 1 upvotes 6 months ago

The conversation discusses the need for a localized 5-alpha reductase inhibitor that only affects the scalp without systemic side effects, similar to pyrilutamide's approach. Current treatments like topical liposomal finasteride and dutasteride are mentioned, but concerns about their systemic effects and lack of research are highlighted.

community Hair progress over 7 years (Oral fin 1mg + oral min 2.5mg + topical min 5% + micro-needling)

in Progress Pictures 194 upvotes 1 year ago

The user shared a 7-year hair progress journey, starting with occasional minoxidil use and later including a finasteride prescription, online prescriptions, and microneedling. Significant hair growth was achieved, but side effects led to a reduction in medication dosage.

community Do people still use microneedling?

in Treatment 10 upvotes 2 months ago

Microneedling is still considered effective for hair growth, especially when combined with minoxidil, though it is time-consuming. Some users report significant success with consistent use, while others find it less popular due to the effort required compared to topical treatments alone.

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