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research Significant effects of mild endogenous hormonal changes in humans: considerations for low-dose testing.

30 citations , March 2001 in “Environmental Health Perspectives”

This review explores the significant impacts of hormonal changes within normal physiological ranges and suggests examining low-dose effects from chemicals disrupting hormonal activity; it presents no new clinical results.

research Significant Effects of Mild Endogenous Hormonal Changes in Humans: Considerations for Low-Dose Testing

2 citations , March 2001 in “Environmental Health Perspectives”

Small hormonal imbalances can cause significant health problems, so more sensitive testing for hormone-disrupting chemicals is needed.

research MP38-07 VASCULAR, NEUROLOGIC AND HORMONAL ABNORMALITIES IN MEN WITH PERSISTENT SEXUAL DYSFUNCTION AFTER DISCONTINUATION OF FINASTERIDE

April 2022 in “The Journal of Urology”

In this study, men with persistent sexual dysfunction after stopping finasteride showed significant vascular, neurologic, and hormonal abnormalities, with severe erectile dysfunction being common.

research European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity

175 citations , January 2020 in “European Journal of Endocrinology”

These guidelines recommend testing thyroid function in patients with obesity due to common hypothyroidism, and highlight that weight loss is crucial for addressing hormonal imbalances, with only modest weight loss benefits from treating endocrine disorders.

research Identifying 17-β-HSD3 Deficiency in Patients with Karyotype 46,XY Misdiagnosed with Androgen Insensitivity Syndrome: A Pediatric Case Report

August 2025 in “American Journal of Case Reports”

In this case report, researchers describe a 13-year-old phenotypic female with 46,XY karyotype, previously misdiagnosed with androgen insensitivity syndrome, who was later identified to have 17-beta-hydroxysteroid dehydrogenase type 3 deficiency, underscoring the importance of genetic and hormonal tests for accurate diagnosis of sex development disorders.

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community Does anyone get blood tests while taking Finasteride to ensure thing are working appropriately (e.g. DHT is decreasing and estrogen isn't increasing significantly)

in Finasteride/Dutasteride 11 upvotes 1 year ago

People are discussing the use of finasteride for hair loss and the importance of hormonal blood testing to monitor effects like changes in DHT and estradiol levels. Some users also mention using minoxidil and the potential side effects of estradiol, such as gynecomastia, especially at higher doses.

community Latest study on RU58841 done 19. August 2026.

25 upvotes 1 month ago

RU58841 can be absorbed systemically after topical application, but the study did not find immediate hormonal disruption. The study highlights the need for more research on long-term safety and effects of RU58841, as well as the importance of quality control in products from the grey market.

community Has anyone stabilized their hair loss on fin and then switched to RU?

4 upvotes 6 months ago

The conversation discusses switching from oral finasteride to topical RU58841 for hair loss, with concerns about hormonal effects and libido. Some users suggest alternatives like dutasteride, while others share mixed experiences with RU58841's effectiveness.

community Why some people experience problems on Finasteride/Dutasteride (my theory)

in Research/Science 18 upvotes 9 months ago

Some people have side effects from finasteride and dutasteride due to hormonal predisposition, especially if DHT dominant. Alternatives like RU58841, Pyrilutamide, and Breezula are suggested to target scalp androgen receptors without altering overall hormones.

community Should I Get Blood Tests to Verify That DUT Is Working? And Is There an Interaction with Quercetin?

1 upvotes 1 year ago

The conversation discusses whether to get a blood test to check DHT levels while using Dutasteride for hair loss and concerns about Quercetin's potential interaction with Dutasteride. It concludes that testing DHT isn't necessary unless no effects are seen, and the small amount of Quercetin in a multivitamin likely doesn't interfere with treatment.

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learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Lavender

Is lavender effective for hormonal hair loss or just stress? Lavender may help with stress-related hair loss but has limited evidence for hormonal hair loss.

learn procapil

Want to stop hormonal hair loss without touching your hormone levels? Procapil could block the enzyme doing the damage. Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

learn Baicapil

Losing hair from hormonal imbalance? Baicapil might block DHT without messing with your hormones. No published study shows that Baicapil blocks DHT — the only data on the ingredient itself is the manufacturer's own unpublished dossier, and the baicalin research behind the claim is cancer cell-line work in which the effect was explicitly independent of the androgen receptor.

learn Adenosine

Adenosine : Can it help if my hair loss is due to a hormonal imbalance like PCOS or DHT? Adenosine may help improve hair growth affected by hormonal imbalances like PCOS or DHT.

learn Bicalutamide

Why are some women using bicalutamide to fight hormonal hair loss? Bicalutamide blocks androgens, helping women combat hormonal hair loss effectively.

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