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research Phytochemicals as Modulators of Human Endocrine Function: Bridging Traditional Remedies and Hormonal Health

December 2025

This chapter explores the potential of phytochemicals in modulating human endocrine function, emphasizing the growing interest in plant-derived alternatives to synthetic medications for managing metabolic and hormonal disorders often linked to chemical exposures and lifestyle factors.

research Berberine as a Modulator of Metabolic and Hormonal Dysregulation in PCOS: Mechanisms of Action and Clinical Implications - A Narrative Review

May 2026 in “Quality in Sport”

This study suggests that berberine may offer multiple benefits for women with polycystic ovary syndrome by improving metabolic and hormonal profiles, though further research is needed on its long-term effects on reproductive outcomes.

research Pharmacologic Modulation of Sebaceous Gland Activity: Mechanisms and Clinical Applications

30 citations , April 2007 in “Dermatologic Clinics”

This review discusses the mechanisms by which isotretinoin and hormonal therapy treat acne through their effects on sebaceous glands, reporting no new clinical results.

research Ferulic acid inhibits catamenial epilepsy through modulation of female hormones

August 2022 in “Metabolic Brain Disease”

In this study with a mouse model of catamenial epilepsy, ferulic acid may effectively reduce seizure susceptibility and depression-like behavior by influencing hormone levels and neurotransmitter activity.

research Sexually dimorphic sail feathers in the Mandarin duck as a model for lifelong developmental modulation

1 citations , October 2025 in “Scientific Reports”

This study investigated the Mandarin duck as a model for understanding lifelong developmental changes, finding that male sail feather morphogenesis involves a combination of local morphogenetic programs, epigenetic regulation, and hormonal cues, with increased female estrogen levels observed before the mating season.

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Community Join

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community Attempting to assist people with gyno sides on finasteride

23 upvotes 2 years ago

Finasteride can cause gynecomastia due to hormonal imbalances. Management includes consulting an endocrinologist and using aromatase inhibitors like anastrozole or supplements like DIM and zinc.

community DHT Isn't (Directly) Important

101 upvotes 1 year ago

Finasteride's potential side effects, especially sexual dysfunction, are discussed, with emphasis on hormonal balance between testosterone and estradiol. Users share experiences with finasteride, minoxidil, and dutasteride, highlighting the variability in side effects and the influence of mindset and lifestyle.

community I cannot even tolerate Nutrafol

in Product 6 upvotes 10 months ago

The user experienced side effects from finasteride and Nutrafol, opting for non-hormonal treatments like minoxidil, exercise, and a healthy lifestyle. Others discussed using Dutasteride, Biotin, and minoxidil with varying success and side effects.

community Marijuana and hair loss?

6 upvotes 10 years ago

The conversation discusses the potential impact of marijuana on hair loss, with some users suggesting it may worsen hair loss due to hormonal changes, while others believe it might alter perception rather than cause actual thinning. The original poster uses Propecia (finasteride) and Rogaine (minoxidil) for treatment and is considering quitting marijuana to see if it affects hair health.

community DHT results after 1 year on dutasteride, confused and seeking guidance

in Finasteride/Dutasteride 107 upvotes 1 year ago

The user is experiencing rapid hair loss despite using dutasteride, finasteride, and minoxidil, and is concerned about high estradiol and testosterone levels. They are advised to consult an endocrinologist for potential hormonal imbalances.

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Learn

10 / 801 results

learn Sulforaphane

compound from cruciferous vegetables has some mild effects on DHT

learn Metformin

diabetes drug with anti-inflammatory, immunomodulatory, and insulin-sensitizing properties

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Thymosin Beta 4

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Lavender

Is lavender effective for hormonal hair loss or just stress? Lavender may help with stress-related hair loss but has limited evidence for hormonal hair loss.

learn procapil

Want to stop hormonal hair loss without touching your hormone levels? Procapil could block the enzyme doing the damage. Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

learn Baicapil

Losing hair from hormonal imbalance? Baicapil might block DHT without messing with your hormones. No published study shows that Baicapil blocks DHT — the only data on the ingredient itself is the manufacturer's own unpublished dossier, and the baicalin research behind the claim is cancer cell-line work in which the effect was explicitly independent of the androgen receptor.

learn Adenosine

Adenosine : Can it help if my hair loss is due to a hormonal imbalance like PCOS or DHT? Adenosine may help improve hair growth affected by hormonal imbalances like PCOS or DHT.

learn Bicalutamide

Why are some women using bicalutamide to fight hormonal hair loss? Bicalutamide blocks androgens, helping women combat hormonal hair loss effectively.

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