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research Correlation of clinical and trichoscopy features with the degree of histologic inflammation in lichen planopilaris and frontal fibrosing alopecia in a cross-sectional study

4 citations , March 2024 in “Journal of the American Academy of Dermatology”

Clinical signs don't match inflammation levels in lichen planopilaris and frontal fibrosing alopecia.

research Pattern hair loss: Assessment of inflammation and fibrosis on histologic sections

7 citations , September 2019 in “Journal of The American Academy of Dermatology”

This study found inflammation and fibrosis in both pattern hair loss cases and controls but concluded that these factors may not significantly contribute to the pathogenesis of pattern hair loss.

research Angiosarcoma of the Scalp Mimicking an Inflammatory Scarring Alopecia and Diagnosed on Horizontal Histologic Sections

1 citations , November 2024 in “Journal of Cutaneous Pathology”

This case study reported on a 72-year-old woman initially diagnosed with inflammatory alopecia, later identified as having angiosarcoma of the scalp, revealing the importance of considering unexpected malignancies during evaluation of suspected inflammatory alopecia cases.

research Frontal Fibrosing Alopecia Involving the Limbs Shows Inflammatory Pattern on Histology: A Review of 13 Cases

7 citations , August 2019 in “American Journal of Dermatopathology”

This study found that limb hair loss in frontal fibrosing alopecia is inflammatory and permanent, but lacks the classic scarring features seen in scalp alopecia, prompting potential misdiagnosis as alopecia areata.

research Reply to comment on: Pattern hair loss. Assessment of inflammation and fibrosis on histologic sections

1 citations , May 2020 in “Journal of The American Academy of Dermatology”

This correspondence highlights existing research on pattern hair loss, discussing findings about immune deposits, lymphocytic infiltration, and responses to treatment, and calls for future well-controlled studies.

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community DHT Harms Scalp Microbiome: DHT Itch is REAL

413 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community Blocking dht should bring it back. So why does fin mostly just hold the line?

17 upvotes 3 months ago

Finasteride mainly prevents further hair loss by blocking DHT but doesn't reverse existing damage, while minoxidil can promote regrowth by waking dormant follicles. Ketoconazole helps with inflammation, but none of these treatments can reverse fibrosis or structural changes around hair follicles.

community Perifollicular Fibrosis and its role in androgenetic alopecia. Is Aminexil/Kopexil a must for anyone with AGA?

5 upvotes 4 years ago

Aminexil/Kopexil may help reduce hair loss by addressing perifollicular fibrosis in androgenetic alopecia, but it lacks the extensive clinical backing of finasteride and minoxidil. Some users find it effective, but availability and cost are issues, especially in the US where it's not FDA-approved.

community Microneedling Isn’t Snake Oil — It’s Evidence-Based. Let’s Talk Studies, Not Fear.

41 upvotes 1 year ago

Microneedling is supported by research as an effective adjuvant treatment for hair loss, especially when combined with Minoxidil or Finasteride, with minimal side effects if done properly. Concerns about long-term safety and potential risks like infection or fibrosis remain, but many users report positive results.

community Hair loss research focused on chemistry for decades because we misunderstood the mechanics of growth.

51 upvotes 7 months ago

Hair growth relies on mechanical forces, not just chemicals, with tissue acting like a motor. Minoxidil and finasteride help, but maintaining tissue elasticity and addressing mechanical issues are essential.

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