269 citations
,
May 2002 in “Hormones and Behavior” Lowering 3α,5α-THP in the hippocampus increases anxiety and depression in proestrous rats.
83 citations
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July 2004 in “Pharmacology Biochemistry and Behavior” Higher 3α,5α-THP levels in the brain may reduce depression in pregnant rats.
82 citations
,
July 2011 in “Journal of Neuroscience” In this study, ethanol was found to enhance GABAergic neurosteroid production and inhibit long-term potentiation in rat hippocampal slices via unblocked NMDA receptor activation, effects reversible by specific inhibitors.
61 citations
,
April 2018 in “Frontiers in endocrinology” This review discusses the local production and role of sex steroids in the hippocampal neurons of adult rodents and reports no new experimental findings.
32 citations
,
May 2010 in “Pharmacopsychiatry” This article investigates whether finasteride influences adult hippocampal neurogenesis related to depression and reports no new clinical findings; the authors suggest further research on its neurosteroid inhibition.