Dosimetric Analysis of the Alopecia Preventing Effect of Hippocampus Sparing Whole Brain Radiation Therapy

November 2015 in “ Radiation Oncology ”

Anand Mahadevan, Christian E. Sampson, Salvatore A. Larosa, Scott Floyd, Eric T. Wong, Erik J. Uhlmann, Soma Sengupta, Ekkehard M. Kasper

alopecia hippocampus sparing whole brain radiation therapy HS-WBRT intensity modulated radiation therapy IMRT follicle-bearing scalp whole brain radiation therapy WBRT hair loss

TLDR Hippocampus sparing whole brain radiation therapy prevents hair loss and preserves cognitive function.

The study concluded that hippocampus sparing whole brain radiation therapy (HS-WBRT) effectively prevented alopecia in patients treated for brain metastases by delivering significantly lower mean doses to the scalp compared to conventional WBRT. Six patients who received HS-WBRT showed full preservation of scalp hair and maintained cognitive function 1-3 months post-treatment. The findings suggested that HS-WBRT could enhance the quality of life by mitigating both cognitive decline and hair loss, making it a promising treatment option for further evaluation.

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