Dosimetric Analysis of the Alopecia Preventing Effect of Hippocampus Sparing Whole Brain Radiation Therapy

    November 2015 in “ Radiation Oncology ”
    Anand Mahadevan, Christian E. Sampson, Salvatore A. Larosa, Scott Floyd, Eric T. Wong, Erik J. Uhlmann, Soma Sengupta, Ekkehard M. Kasper
    TLDR Hippocampus sparing whole brain radiation therapy prevents hair loss and preserves cognitive function.
    This study demonstrated that hippocampus sparing whole brain radiation therapy (HS-WBRT) using multi-field intensity modulated radiation therapy (IMRT) effectively reduced the dose to follicle-bearing scalp and prevented alopecia in patients. Six patients who met the RTOG 0933 trial criteria received HS-WBRT and showed full scalp hair preservation and no cognitive decline 1-3 months post-treatment. Compared to conventional WBRT, HS-WBRT significantly lowered the mean dose (22.42 cGy vs. 16.33 cGy, p < 0.0001) and volume of scalp receiving higher doses (V24 and V30), thus preventing hair loss. No recurrences were observed in the hippocampus area.
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