This study suggests that low-doseIL-2 and IL-15 may help restore immune tolerance in alopecia areata by maintaining Treg cell function, presenting a potential new treatment strategy.
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January 2023 in “International Journal of Molecular Sciences”
This review explores the role of Tregs in autoimmune skin diseases, transplantation, and skin cancer, and discusses Tregs-based therapies' potential for treating autoimmunity without reporting new experimental results.
September 1997 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”
Anti-IL-1 treatments might help with certain types of hair loss in people with high inflammation.
In this study, 2′‐Fucosyllactose (2′‐FL) administration significantly reduced hair loss and increased hair length and thickness in a testosterone-induced androgenic alopecia mouse model, suggesting potential as a therapeutic agent for AGA.
The user saw no significant changes in hair loss after three months on 3mg Dutasteride, having previously used Finasteride and 0.5mg Dutasteride. They plan to continue the highdose for a year despite concerns about side effects and diminishing returns.
The user experienced significant hair regrowth in two months using minoxidil foam and 0.5mg finasteride every other day, despite some side effects. They are considering adjusting the finasteride dosage and possibly adding biotin or dermarolling to their routine.
Pumpkin seed oil is considered a weak DHT blocker compared to finasteride and dutasteride, with some users reporting side effects like mood changes and reduced libido. Despite some anecdotal benefits for urinary issues, it is not effective for hair loss, and finasteride is preferred by some users for its lack of side effects.
A 21-year-old has been using finasteride for 6.5 months, starting with 0.25 mg daily and increasing to 0.5 mg, experiencing improved hair quality and no significant side effects. They have not used minoxidil due to convenience and health reasons, and they noticed progress in hair growth, particularly at the crown, after about 4 months.
Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.