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Hypoxia-Inducible Factor 1-alpha

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Deletion of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2 in FoxD1-Lineage Mesenchymal Cells Leads to Congenital Truncal Alopecia

research Deletion of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2 in FoxD1-Lineage Mesenchymal Cells Leads to Congenital Truncal Alopecia

March 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

Removing a specific gene in certain skin cells causes hair loss on the body by disrupting normal hair development.

research Deletion of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2 in FoxD1-Lineage Mesenchymal Cells Leads to Congenital Truncal Alopecia

1 citations , October 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

Removing HIF-P4H-2 from certain skin cells in mice causes hair loss on the body but not the head.

research Deletion of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2 in FoxD1-Lineage Mesenchymal Cells Leads to Congenital Truncal Alopecia

1 citations , March 2022 in “Journal of biological chemistry/The Journal of biological chemistry”

Removing a specific gene in certain skin cells causes hair loss in mice by disrupting hair follicle development.

research Oxygen, Metabolism, and Regeneration: Lessons from Mice

35 citations , October 2017 in “Trends in Molecular Medicine”

Mice with enhanced regeneration abilities may help develop new regenerative medicine therapies.

research HIF1A Stabilization in the Human Hair Follicle Promotes Glycolysis

April 2018 in “Journal of Investigative Dermatology”

Stabilizing HIF1A in hair follicles increases glycolysis, which may help reduce oxidative stress and support hair growth.

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community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 486 upvotes 1 year ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community New Study and Product: Tomorrowlabs HSF

in Research/Science 7 upvotes 2 years ago

New product Tomorrowlabs HSF targets hair loss through HIF pathway indirectly by removing scalp iron. Minoxidil and Stemoxydine also relate to HIF pathway.

community Update about Hair Follicle Glucose Metabolism: New Clinical Data Collection with Ex-President Of American Board Of Hair Restoration Surgery.

in Research/Science 42 upvotes 1 year ago

David Barreto shared that a London-based research group is conducting a 12-month trial for a new nutraceutical treatment for pattern hair loss, designed with Dr. Carlos Puig. The trial aims to provide robust data, with results expected in 1-2 years, potentially representing a significant advancement since finasteride’s introduction in 1997.

community The mechanism of androgenic alopecia

in Research/Science 33 upvotes 5 months ago

DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

community My Theory Of Androgenic Alopecia

in Research/Science 19 upvotes 3 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

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