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GlossaryHypoxia-Inducible Factor 1-alpha (HIF1A)

protein that helps cells adapt to low oxygen levels

Hypoxia-Inducible Factor 1-alpha (HIF-1α) is a protein that helps cells respond to low oxygen levels (hypoxia). It activates various genes that enable cells to adapt to hypoxic conditions, such as those involved in increasing blood supply and altering metabolism. This protein is crucial in processes like wound healing and can also play a role in diseases like cancer, where it can help tumors grow by improving their oxygen supply.

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Transgenic Erythropoietin Overexpression Inhibits Dermal Fat Formation and HIF1a in the Skin and Causes Telogen Effluvium in Mouse Pups During the First Hair Cycle

research Transgenic Erythropoietin Overexpression Inhibits Dermal Fat Formation and HIF1a in the Skin and Causes Telogen Effluvium in Mouse Pups During the First Hair Cycle

June 2024 in “Diabetes”

Erythropoietin overexpression disrupts hair growth and fat formation in mice.

research HIF1A Stabilization in the ORS of Human Hair Follicles Promotes Aerobic Glycolysis and Synthesis of Angiogenic Factors

April 2019 in “Journal of Investigative Dermatology”

Stabilizing HIF1A in hair follicles may boost hair growth by enhancing energy production and blood vessel formation.

research HIF1A Stabilization in the Human Hair Follicle Promotes Glycolysis

April 2018 in “Journal of Investigative Dermatology”

Stabilizing HIF1A in hair follicles increases glycolysis, which may help reduce oxidative stress and support hair growth.

research Scarless Wound Healing: Transitioning from Fetal Research to Regenerative Healing

79 citations , January 2018 in “Wiley Interdisciplinary Reviews-Developmental Biology”

Understanding how baby skin heals without scars could help develop treatments for adults to heal wounds without leaving scars.

research Factors Regulating Quiescent Stem Cells: Insights from the Intestine and Other Self-Renewing Tissues

8 citations , December 2015 in “The Journal of Physiology”

The document concludes that stem cell inactivity is actively controlled and important for tissue repair and balance.

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community 48 Days Fin, Min, and Derm Part 2

in Progress Pictures 264 upvotes 2 years ago

The user discussed their positive experience with hair loss treatments Finasteride, Minoxidil, and Dermarolling, showing significant progress in 48 days. Other users expressed interest in trying these treatments, asked about side effects, and one noted that they've observed good results in black people.

community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

in Research/Science 92 upvotes 3 years ago

The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

community The mechanism of androgenic alopecia

in Research/Science 32 upvotes 2 months ago

DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 479 upvotes 1 year ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Update about Hair Follicle Glucose Metabolism: New Clinical Data Collection with Ex-President Of American Board Of Hair Restoration Surgery.

in Research/Science 43 upvotes 1 year ago

David Barreto shared that a London-based research group is conducting a 12-month trial for a new nutraceutical treatment for pattern hair loss, designed with Dr. Carlos Puig. The trial aims to provide robust data, with results expected in 1-2 years, potentially representing a significant advancement since finasteride’s introduction in 1997.