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GlossaryHereditary Hypotrichosis Simplex (HHS)

genetic condition causing progressive hair thinning and loss

Hereditary Hypotrichosis Simplex (HHS) is a genetic condition characterized by progressive hair thinning and loss, typically beginning in childhood or adolescence. Unlike other forms of hair loss, HHS does not involve scarring or other skin abnormalities, and it primarily affects the scalp, leading to sparse or absent hair over time.

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research APCDD1 Is a Novel Wnt Inhibitor Mutated in Hereditary Hypotrichosis Simplex

199 citations, April 2010 in “Nature”

A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.

research A New Locus for Hereditary Hypotrichosis Simplex Maps to Chromosome 13q12.12-12.3 in a Chinese Family

7 citations, May 2010 in “Journal of Cutaneous Pathology”

A new genetic area linked to a rare hair loss condition was found on chromosome 13 in a Chinese family.

research Isotretinoin-Induced Hair Growth in a Case of Hereditary Hypotrichosis Simplex of the Scalp: A Promising Therapeutic Approach

July 2024 in “JAAD Case Reports”

Isotretinoin may effectively treat hereditary hypotrichosis simplex, a rare hair loss condition.

research Hair: More Than Just an Appendage

June 2021 in “International journal of research in dermatology”

A boy and his father with hereditary hypotrichosis simplex were treated for hair loss, but the treatment result is unknown.

research Correlation Between In Vivo Reflectance Confocal Microscopy and Horizontal Histopathology in Skin Cancer: A Review

13 citations, March 2021 in “Frontiers in oncology”

Reflectance confocal microscopy reliably identifies skin cancer features like horizontal skin tissue sections.

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