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research From Basal Cell Carcinoma Morphogenesis to Alopecia Induced by Hedgehog Inhibitors: Connecting the Dots

17 citations, June 2017 in “British Journal of Dermatology”

The article concludes that hair loss is a common side effect of drugs treating skin cancer by blocking the hedgehog pathway, but treatment should continue, and more selective drugs might prevent this side effect.

research Oncogenes and Morphogens: Intricacies of Targeted Therapy in Cutaneous Basal Cell Carcinoma

December 2017 in “British Journal of Dermatology”

Targeted therapy for skin cancer is complex due to the role of the hedgehog pathway in both cancer and hair growth.

Anti-Basal Cell Carcinoma Efficacy of a Topical Hedgehog Inhibitor Without Adverse Effects in Gorlin Syndrome Patients in a Phase 2 Randomized Controlled Trial

research Anti-Basal Cell Carcinoma Efficacy of a Topical Hedgehog Inhibitor Without Adverse Effects in Gorlin Syndrome Patients in a Phase 2 Randomized Controlled Trial

1 citations, April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Topical patidegib gel effectively treats basal cell carcinoma in Gorlin syndrome patients without causing the side effects seen with oral treatments.

research Understanding Cancer Cells of Origin in Cutaneous Tumors

1 citations, January 2016 in “Elsevier eBooks”

The document concludes that identifying the specific cells where skin cancers begin is important for creating better prevention, detection, and treatment methods.

research Aberrant Activation of the Hedgehog Signaling Pathway in Malignant Hematological Neoplasms

68 citations, November 2011 in “The American journal of pathology”

Abnormal Hedgehog signaling in blood cancers may help tumors grow and resist chemotherapy, suggesting potential for targeted treatments.

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community How insane is this oral min shed?

in Progress Pictures 111 upvotes 1 year ago

A user started taking 0.625mg oral minoxidil daily for hair loss, increased the dose to 1.25mg, and experienced a significant shed, losing 70% of scalp density. They cannot tolerate finasteride due to side effects but are hopeful for hair regrowth despite the shedding.

community Topical Finasteride strength discussion

in Research/Science 65 upvotes 1 year ago

The conversation discusses the effectiveness of different concentrations and dosages of topical finasteride on scalp and serum DHT levels, comparing it to oral finasteride and noting the side effects seem to be fewer at lower dosages. Participants shared experiences and referenced a chart indicating similar scalp DHT reduction with 0.025% topical finasteride as with 1mg oral finasteride, but with fewer side effects.

community Topical finasteride now the safest possible path?

in Finasteride/Dutasteride 84 upvotes 10 months ago

Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.

community Found a Pharmacy that will mix me 0.1 % Alfatradiol (Pantostin)

in Treatment 6 upvotes 9 months ago

The user is currently using 0.025% Pantostin but plans to switch to 0.1% Alfatradiol. They will also use high-dose Kx826, high-dose Minoxidil, and aggressive microneedling for hair regrowth.

community Finasteride only: Before vs 11 months

in Progress Pictures 437 upvotes 10 months ago

A user shared progress pictures showing hair improvement after 11 months of using finasteride. The user experienced minimal shedding and plans to continue the treatment long-term.

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