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research (Neuro-)endocrinology of epithelial hair follicle stem cells
Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.
research Hair follicle-derived epithelial sheet has potential in vitiligo treatment
The study explores the use of hair follicle-derived epithelial sheets (HFES) as a novel treatment for vitiligo, addressing the limitations of autologous cultured epithelial grafts (ACEG) which can cause scarring. By optimizing culture conditions, researchers maintained undifferentiated hair follicle cells and directed them to form a multi-layered, epidermis-like sheet. The HFES showed promising results in terms of cell identity, viability, purity, genomic stability, and safety. Immunofluorescence staining indicated that basal keratinocytes were predominant, and transcriptomic analysis revealed increased melanocyte proliferation and melanosome maturation. Transplantation of HFES in patients with stable vitiligo led to successful skin repigmentation, offering a new therapeutic option for vitiligo management.
research 599 PPARg signaling modulation protects from hair follicle bulge stem cell damage and cyclophosphamide-induced hair follicle cytotoxicity
PPARγ signaling modulation can protect hair follicle stem cells from chemotherapy-induced damage.
research 1380 PPAR-γ modulation as a novel therapeutic strategy for scarring alopecia
A new treatment using AGED to modulate PPAR-γ shows promise for treating scarring hair loss by protecting and repairing hair follicle cells.
research 269 The PPAR-γ modulator, N-acetyl-GED, protects from epithelial-mesenchymal-transition to human hair follicles: Potential relevance for scarring alopecia
N-acetyl-GED may help prevent and partially reverse a process that leads to scarring hair loss.
Community Join
5 / 1000+ resultscommunity if hmi-115 truly works, we can just get off off fin?
A potential new hair loss treatment, HMI-115, and the possibility of discontinuing finasteride in favor of it. The conversation also includes discussion about other benefits of using finasteride.
community HLT Megathread on HMI-115 (key takeaways in comments)
HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.
community How did you feel about HIMS?
The user is concerned about the quick prescription process for hair loss treatments like Minoxidil and Finasteride through HIMs, questioning the lack of a thorough evaluation. Another user reassures that such practices are common, emphasizing the effectiveness and low risk of these treatments, and suggests monitoring personal response to the medication.
community Has Anyone Heard About Ethossomal Finasteride? 6x Finasteride Delivery in Hair Folicule?
A user is considering switching from oral to topical finasteride to reduce systemic DHT impact and is exploring ethossomal finasteride for better skin penetration and potential hair regrowth. They found ethossomal finasteride in Brazil and are seeking opinions on its effectiveness compared to other topical delivery methods.
community EMAs Response to my Mail i sent them explaining the importance of Finasteride for hairloss in EU
The conversation discusses the importance of Finasteride for hair loss treatment in the EU and encourages individuals to voice their support to the EMA. It highlights the potential influence of public input on regulatory decisions.