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Smad1 and Smad5 but Not Smad8 Establish Stem Cell Quiescence Critical for Transforming Premature Hair Follicles During Morphogenesis to the Postnatal State

research Smad1 and Smad5 but Not Smad8 Establish Stem Cell Quiescence Critical for Transforming Premature Hair Follicles During Morphogenesis to the Postnatal State

31 citations, September 2013 in “Stem Cells”

Smad1 and Smad5 are essential for hair follicle development and stem cell sleepiness.

research There And Back Again: Hair Follicle Stem Cell Dynamics

4 citations, January 2011 in “Cell stem cell”

Hair follicle stem cells can return to their original niche and help regenerate hair.

research Signaling Involved in Hair Follicle Morphogenesis and Development

223 citations, January 2014 in “International Journal of Molecular Sciences”

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

research Epidermal Stem Cell Diversity and Quiescence

168 citations, August 2009 in “EMBO molecular medicine”

Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.

research Exosomal MicroRNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation

71 citations, January 2019 in “International journal of biological sciences”

Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.

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community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community HairClone developing cell replacement treatments for Hair Loss

6 upvotes 6 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.

community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community Hair follicle cloning is already possible

in Chat 38 upvotes 2 months ago

Hair follicle cloning is claimed to be possible but not widely available due to potential safety issues, such as cancer risks. Current treatments like finasteride and dutasteride are not effective for everyone, and there is frustration over limited access to these medications.

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