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GlossaryHepatotoxicity

refers to liver damage caused by chemicals or drugs

Hepatotoxicity, also known as liver toxicity, refers to liver damage caused by chemicals, drugs, or natural substances. It can result in a range of liver dysfunctions, from mild enzyme elevations to severe liver failure. This condition is significant in both clinical and pharmacological contexts, as the liver plays a crucial role in metabolizing substances, and its impairment can lead to serious health consequences.

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research PH Sensitive Nano Layered Double Hydroxides Reduce the Hematotoxicity and Enhance the Anticancer Efficacy of Etoposide on Non-Small Cell Lung Cancer

65 citations, October 2015 in “Acta Biomaterialia”

The nano-carrier makes etoposide safer and more effective against lung cancer.

research Severe Thiopurine-Induced Myelotoxicity and Hair Loss in Japanese Patients with NUDT15 Gene Variant: A Retrospective Case-Control Study

April 2018 in “Journal of Investigative Dermatology”

Screening for the NUDT15 gene variant can prevent severe side effects from thiopurine drugs in East-Asian people.

research Tyrosine Kinase Inhibitors Against Cancer: Their Safety in 216 Moroccan Patients

January 2021 in “Journal of Cancer Therapy”

Tyrosine Kinase Inhibitors are effective against cancer but can cause skin, digestive, and blood side effects, including hair loss.

research Bendamustine in Indolent Non-Hodgkin's Lymphoma: A Practice Guide for Patient Management

24 citations, July 2013 in “Oncologist”

Bendamustine combined with rituximab is an effective and well-tolerated treatment for certain types of lymphoma.

research Compilation of a Comprehensive Gene Panel for Systematic Assessment of Genes That Govern an Individual’s Drug Responses

13 citations, October 2010 in “Pharmacogenomics”

Researchers found that most genes affecting drug responses are not fully covered by commercial SNP chips, suggesting the need for more comprehensive tools to optimize drug selection based on genetics.

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