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The conversation discusses the perception of increased hair loss among young men, with some attributing it to heightened awareness or environmental factors. Various treatments are mentioned, including Minoxidil, Finasteride, microneedling, scalp massages, and future hair transplant methods.

A user is frustrated about early balding despite older male relatives retaining hair into old age. Another user plans to start finasteride soon to address their hair thinning.

OP reports that after 3 months on 2.5mg dutasteride, their hair has stopped falling out and is thick again, but they are considering stopping due to potential mood and energy side effects. Other users discuss experiences with finasteride, dutasteride, and side effects, with some suggesting lower doses or alternative treatments like topical applications.

A 21-year-old male experiencing severe hair shedding despite using 1mg finasteride, 2.5mg oral minoxidil, and saw palmetto with pumpkin seed oil. He is seeking advice on whether this shedding is normal and if he should consider other treatments like dutasteride or RU58841.

FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.