13 citations
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August 2021 in “Frontiers in Aging Neuroscience” Hearing decline in SAMP8 mice starts before outer hair cell loss and may be linked to other changes.
September 2023 in “Curēus” Alopecia areata may be linked to hearing problems, so patients should monitor their hearing.
17 citations
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April 2021 in “Frontiers in Pharmacology” Activating Nrf2 can help protect against hearing loss.
5 citations
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October 2015 in “The Egyptian Journal of Otolaryngology” Alopecia areata patients may have hearing loss linked to the condition's severity and duration.
The study explores the role of the oncomodulin gene pvalb8 in zebrafish, emphasizing its importance in neuromast development and auditory function. Pvalb8 is crucial for hair cell development, with its mutation leading to neuromast defects and hearing loss. The study shows that pvalb8 regulates hair cell development through Wnt-dependent signaling, as activating this pathway can rescue hair cell loss in mutants. Pvalb8 deficiency reduces Wnt target gene expression, leading to fewer hair cells, but treatment with a Wnt activator can partially restore these deficits. The research suggests that pvalb8 and its mammalian counterpart, OCM, could be targets for hearing disorder treatments, though further investigation is needed to understand the mechanisms involved.