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research In vitro effects of testosterone, dihydrotestosterone and estradiol on cell growth of human hair bulb papilla cells and hair root sheath fibroblasts.

22 citations , July 1990 in “Acta Dermato Venereologica”

In this study, high concentrations of dihydrotestosterone and testosterone reduced the growth of human hair follicle cells in vitro, while high estradiol levels increased their growth.

research Hair Strengthening Evaluation of Anisotropic Osmolite Solutions (Inositol + Arginine): Cross-Talk between Dermal Papilla Fibroblast and Keratinocytes of the Outer Root Sheath Using a µHair Follicle 3D Model

September 2018 in “Cosmetics”

This study found that anisotropic osmolyte solutions may improve hair follicle turnover and condition in both in vitro and in silico models, as well as in human volunteers with hair disorders.

research An osteopontin‐derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor‐7 production in outer root sheath keratinocytes

19 citations , September 2019 in “British Journal of Dermatology”

This study found that a novel peptide, FOL-005, derived from osteopontin, significantly inhibited hair growth in human hair follicles both ex vivo and in vivo, suggesting potential as a treatment for unwanted hair growth.

research Effects of epidermal growth factor, fibroblast growth factor, minoxidil and hydrocortisone on growth kinetics in human hair bulb papilla cells and root sheath fibroblasts cultured in vitro

58 citations , June 1987 in “Archives of Dermatological Research”

This study found that epidermal and fibroblast growth factors increased proliferation of human hair bulb papilla cells and root sheath fibroblasts in vitro, while hydrocortisone decreased it and minoxidil had no effect.

research Epidermal growth factor and fibroblast growth factor accelerate proliferation of human hair bulb papilla cells and root sheath tibroblasts cultured in vitro

9 citations , March 1987 in “British Journal of Dermatology”

This study found that epidermal growth factor and fibroblast growth factor accelerated proliferation of human hair bulb papilla cells and root sheath fibroblasts cultured in vitro.

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community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

373 upvotes 6 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

community Summary of Procapil video by Haircafe

2 upvotes 1 year ago

Procapil is marketed as a natural hair loss treatment but lacks strong evidence and is industry-biased. Minoxidil and Finasteride are the only FDA-approved treatments for androgenetic alopecia.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 3 years ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community Why is minoxidil the “regrowth stimulant” and finasteride “the maintenance”, when official studies show more growth on finasteride ?

in Research/Science 46 upvotes 6 months ago

Finasteride is more effective for long-term hair maintenance by addressing the root cause of hair loss, while minoxidil acts as a growth stimulant with faster visible results. Combining both treatments is optimal, with oral minoxidil often showing better results for some individuals.

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