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research Dynamic expression of the zinc-finger transcription factor Trps1 during hair follicle morphogenesis and cycling

46 citations , November 2007 in “Gene Expression Patterns”

This study observed that Trps1 gene expression in mice is precisely regulated in skin development, particularly during hair follicle morphogenesis, with distinct localization patterns in different cell types.

research Analysing the dynamics of a model for alopecia areata as an autoimmune disorder of hair follicle cycling

11 citations , June 2017 in “Mathematical Medicine and Biology A Journal of the IMA”

This mathematical model of alopecia areata illustrates how inflammatory autoimmune responses interrupt the anagen phase of hair growth, and may help evaluate treatments and identify new therapeutic targets.

research CD10 and CD34 in fetal and adult human hair follicles: dynamic changes in their immunohistochemical expression during embryogenesis and hair cycling

25 citations , July 2008 in “British Journal of Dermatology”

This study observed dynamic changes in CD10 and CD34 expression in fetal and adult human hair follicles during embryogenesis and hair cycling.

research The Skin Microenvironment: A Dynamic Regulator of Hair Follicle Development, Cycling and Disease

September 2025 in “Biomolecules”

This review analyzed the complex interactions within the skin microenvironment that influence hair follicle development and regeneration, exploring its role in hair-related disease treatment and highlighting research challenges and future directions.

research Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: An update

52 citations , October 2012 in “Journal of Dermatological Science”

This review presents updated tables of mouse mutants with hair growth abnormalities to aid in understanding the molecular mechanisms of human hair disorders, but reports no new clinical results.

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community Hair loss research focused on chemistry for decades because we misunderstood the mechanics of growth.

51 upvotes 7 months ago

Hair growth relies on mechanical forces, not just chemicals, with tissue acting like a motor. Minoxidil and finasteride help, but maintaining tissue elasticity and addressing mechanical issues are essential.

community Has anyone powered through the creatine shedding (via increased androgen receptor sensitivity) and stabilized?

9 upvotes 1 year ago

Creatine may cause increased hair shedding due to androgen receptor sensitivity, despite limited evidence. The user is using dutasteride and minoxidil and seeks advice on whether shedding will stabilize, with suggestions including GHK-Cu and RU58841.

community Scalp Skin Barrier Health and Hair Follicle Cycling: A Potential Overlooked Connection

in Technology 4 months ago

The conversation discusses the importance of scalp skin barrier health in hair follicle cycling, suggesting treatments like ceramides or niacinamide to support hair growth. It also mentions the use of finasteride for hair loss.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

67 upvotes 11 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community How to correctly dose Saw Palmetto and Pumpkin Seed Oil

in Research/Science 5 upvotes 2 years ago

The user takes 1 mg finasteride three times a week, topical minoxidil daily, and Saw Palmetto both topically and orally on non-finasteride days. They recently added 1 g of pumpkin seed oil daily to improve hair thickness and are seeking advice on dosing and cycling Saw Palmetto.

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