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research Coordinating Stem Cell Behavior in the Hair Follicle

September 2025 in “Digital Commons - RU (Rockefeller University)”

This study found that when NFIB was removed in adult mouse hair follicle stem cells, it did not affect their maintenance but unexpectedly led to increased proliferation and differentiation of nearby melanocyte stem cells.

research Analyses of regenerative wave patterns in adult hair follicle populations reveal macro-environmental regulation of stem cell activity

64 citations , January 2009 in “The International journal of developmental biology”

This study found that intra-follicular Wnt signaling and dermal BMP signaling oscillate differently during hair cycling in mice, affecting hair wave propagation and phases of hair growth.

research The Role of dWAT ‐Immune Crosstalk in Hair Follicle Microenvironment in Hair Regeneration

August 2026 in “The Journal of Dermatology”

In this review, the authors summarize recent findings on dermal white adipose tissue (dWAT), highlighting its crucial role in the hair follicle microenvironment by regulating inflammation and immune responses, thus influencing hair regeneration.

research Regulation of melanocyte stem cell behavior by the niche microenvironment

24 citations , March 2018 in “Pigment Cell & Melanoma Research”

This review discusses the interactions between melanocyte stem cells and their niche in hair regeneration and repair, but reports no new results; recent studies on molecular pathways are highlighted.

research Hypothalamic-pituitary-adrenal axis, hair, and sebum: Stress-mediated dermatologic disasters of the pandemic era

September 2025 in “Cosmoderma”

This study highlights how the COVID-19 pandemic has exacerbated stress-related dermatological issues like acne and hair loss by affecting skin and hair cycles through stress hormones, emphasizing the need for comprehensive psychoneuroendocrine-informed approaches to diagnosis and treatment.

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Community Join

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community Should I avoid a testosterone cycle if I care a lot about keeping my hair?

in Treatment 5 upvotes 1 month ago

Avoid testosterone cycles if you care about hair preservation, as they can accelerate hair loss despite using finasteride. Consider alternatives like dutasteride for better protection against hair loss.

community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

373 upvotes 6 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

community Hair Loss "a matter of survival" in South Korea

335 upvotes 8 months ago

South Korea's president is advocating for hereditary hair loss to be covered by national health insurance due to its impact on mental health and daily functioning. The discussion highlights the societal pressure in South Korea regarding appearance and the potential benefits of treating hair loss to improve mental health.

community My hair progress since Sept 2023

471 upvotes 6 months ago

The user started using finasteride and topical minoxidil in September 2023, later adding a Theradome laser helmet, which helped reduce hair shedding significantly. The user reports improved hair coverage and stability, attributing most progress to the medications rather than the helmet.

community Life with hair is so different. Save your hair!

in Update 625 upvotes 1 year ago

Hair restoration treatments like finasteride, minoxidil, dutasteride, and hair transplants can greatly enhance self-image and dating life. Opinions differ on whether to embrace baldness or pursue treatments for maintaining hair.

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Learn

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learn Dexpanthenol

precursor of vitamin B5 with hair stimulating effects

learn Thymosin Beta 4

learn Stem Cell Factor

learn Hair Transplant

What happens after a hair transplant? Expect mild swelling and redness, with new hair growth starting in 3 to 6 months.
When will I see new hair growth after a hair transplant? New hair growth usually starts 2-4 months after a hair transplant.

learn Cyproterone

How long does it take for cyproterone to work on hair loss? There is no reliable published figure for how fast cyproterone works on hair loss: the hair cycle means nothing shows for months, the one randomised trial assessed women at twelve months, and community reports range from about six months to two years — with some people seeing no change at all.

learn horsetail extract

How long should you use horsetail extract before noticing stronger or thicker hair? No published trial has tested horsetail extract for hair thinning, so no evidence-based timeline exists; the hair cycle means any supplement needs at least three months, and more realistically five to six, before a change could be visible at all.

learn Rapamycin

Is rapamycin safe for long-term use on the scalp, or should it be used in cycles? There is no published human trial of topical rapamycin on the scalp, so nobody knows whether long-term use is safe; the idea of cycling it comes from community practice and theory, not from any study or guideline, and rapamycin for hair loss is an off-label use of a prescription immunosuppressant.

learn Adenosine

nucleoside used for hair regrowth stimulant properties

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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Clinics

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22
Hair Systems
New Horizon Behavioral & Wellness CenterUpper Marlboro, MD · US

Experts

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Unscored
SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas