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research Delayed epidermal permeability barrier formation and hair follicle aberrations in Inv-Cldn6 mice

63 citations , April 2005 in “Mechanisms of development”

This study found that heterozygous mice overexpressing Claudin-6 experienced alterations in epidermal and hair follicle differentiation, leading to distinctive coat characteristics and a disrupted epidermal permeability barrier.

research Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ

218 citations , October 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found that removing PPARγ specifically from mouse adipose tissue led to severe fat loss, insulin resistance, diabetes, and associated metabolic abnormalities.

research Conditional Disruption of Hedgehog Signaling Pathway Defines its Critical Role in Hair Development and Regeneration

194 citations , May 2000 in “Journal of Investigative Dermatology”

This study demonstrated that blocking the Sonic hedgehog signaling pathway in mice led to reversible inhibition of body coat hair morphogenesis, while whisker development was unaffected.

research Runx3 is involved in hair shape determination

34 citations , June 2005 in “Developmental dynamics”

This study found that Runx3 deficiency in mice affects hair type and shape, suggesting it may regulate hair formation through interactions between dermal and epidermal layers.

Expression and Tissue Distribution Analysis of Vimentin and Transthyretin Proteins Associated With Coat Colors in Sheep (Ovis Aries)

research Expression and tissue distribution analysis of vimentin and transthyretin proteins associated with coat colors in sheep (Ovis aries)

June 2023 in “Animal Bioscience”

This study observed that vimentin and transthyretin proteins were more highly expressed in black sheep skins compared to white, suggesting their involvement in coat color formation.

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Community Join

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community Should I get transplant #4 or just shave my head?

in Transplants 171 upvotes 2 years ago

A 36-year-old considering a fourth hair transplant is advised to either shave his head or use a hair system due to poor results from previous transplants and late medication use. He plans to consult top surgeons and adjust his current treatments, including finasteride and minoxidil.

community Topical Fin & Min, 5 Month Progress

1180 upvotes 10 months ago

Significant hair regrowth was achieved using a topical combination of 0.3% finasteride and 6% minoxidil, with weekly dermastamping and ketoconazole shampoo, without side effects. Others suggested additional treatments like red light therapy and PRP.

community Story time! The Great Unbalding (PP405)

230 upvotes 11 months ago

PP405 is a promising new hair loss treatment that may reactivate dormant hair follicles without side effects. It could surpass traditional treatments like minoxidil and finasteride if successful in further trials.

community Finasteride and Eye Problems: You’re Not Going Crazy

in Finasteride/Dutasteride 503 upvotes 1 year ago

Finasteride can cause dry eyes and vision issues due to its impact on the meibomian glands. Users have mixed experiences, with some experiencing eye discomfort and others having no side effects.

community Hair Transplant (Feb 2024) Results

in Progress Pictures 228 upvotes 1 month ago

A user shared progress pictures of their hair transplant results from February 2024, discussing recovery and the time it takes for permanent hair to grow. The conversation includes questions about the procedure, costs, and whether the user is on medications like Minoxidil, Finasteride, or RU58841.

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Learn

1 / 801 results

learn Keratin

Is keratin in shampoos and conditioners actually absorbed by the hair, or does it just coat the surface? Keratin in shampoos mainly coats the hair rather than being absorbed.
Is keratin in shampoos and conditioners actually absorbed by the hair, or does it just coat the surface? Keratin in shampoos and conditioners primarily coats the hair rather than being absorbed.

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Clinics

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Experts

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas