18 citations
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January 2017 in “Annals of dermatology/Annals of Dermatology” This study found that Th17 lymphocytes may play a more crucial role than cytotoxic T cells in the development of alopecia areata due to their infiltration around the hair bulb/bulge, which exacerbates hair loss as histopathological grade worsens.
September 2019 in “Journal of Investigative Dermatology” This study found that in chronic alopecia areata, increased IL-17 expression and CD8+CD49a-Trm cell infiltration in hair follicles were associated with more severe histopathologic gradings, while Foxp3+mTreg infiltration decreased.
20 citations
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December 2010 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This study found that selective downregulation of CD200 in the bulge area might contribute to unusual bulge involvement in a subset of alopecia areata cases.
May 2025 in “International Journal of Trichology” This study found that partially bald scalps of Indian men with androgenic alopecia retain progenitor cells marked by CD34 and Sox9, but these cells are absent in completely bald areas, suggesting that interventions might be more effective if focused on early-stage hair loss.
September 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study observed that while some progenitor cells were present in the partially bald areas of androgenic alopecia in Indian men, the completely bald areas lacked these cells, suggesting potential timing for therapeutic intervention targeting hair follicle stem cell activity.