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This study observed that combining hair dyeing with sodium hydroxide relaxers drastically increased protein loss in Caucasian virgin dark brown hair, while ammonium thioglycolate or guanidine hydroxide relaxers caused less damage.

This study found that glyoxylic acid caused more protein loss in hair compared to traditional alkaline straighteners, though both types of treatments showed comparable effects on hair tensile strength.

This study found that androgenic alopecia is present in 22% of women with polycystic ovary syndrome and is associated with other clinical signs of hyperandrogenism, but not with increased biochemical hyperandrogenemia or metabolic dysfunction.

Hair straightening methods have advanced to improve effectiveness and reduce damage, but still rely on heat and chemicals.

This review discusses hair straightening techniques, products, and safety risks, providing guidance for dermatologists to advise patients effectively; it reports no new clinical results.