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GlossaryGlycogen Synthase Kinase 3 (GSK-3)

enzyme involved in regulating cell functions and signaling pathways

Glycogen Synthase Kinase 3 (GSK-3) is an enzyme that plays a crucial role in various cellular processes, including the regulation of glycogen synthesis, cell division, and cell survival. It is involved in multiple signaling pathways and can influence conditions like diabetes, Alzheimer's disease, and even hair growth by affecting cellular functions and gene expression.

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Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

research Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

95 citations, May 2012 in “British Journal of Dermatology”

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

research The Mechanism of Activated Platelet-Rich Plasma Supernatant Promotion of Hair Growth by Cultured Dermal Papilla Cells

14 citations, March 2019 in “Journal of Cosmetic Dermatology”

Activated platelet-rich plasma helps hair growth by boosting growth factors and cell growth pathways in hair cells.

In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos

research In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos

6 citations, May 2022 in “Frontiers in physiology”

Injecting CHIR-99021 into goose embryos improves feather growth by changing gene activity and energy processes.

Mycophenolate Antagonizes IFN-γ-Induced Catagen-Like Changes via β-Catenin Activation in Human Dermal Papilla Cells and Hair Follicles

research Mycophenolate Antagonizes IFN-γ-Induced Catagen-Like Changes via β-Catenin Activation in Human Dermal Papilla Cells and Hair Follicles

11 citations, September 2014 in “International Journal of Molecular Sciences”

Mycophenolate helps reverse hair loss effects caused by IFN-γ by activating a key hair growth pathway.

research Physiological Functions of PP2A: Lessons from Genetically Modified Mice

87 citations, July 2018 in “Biochimica et Biophysica Acta (BBA) - Molecular Cell Research”

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

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community Why is dutasteride approved for hair loss in Japan and South Korea but not for USA?

in Research/Science 34 upvotes 2 years ago

The reasoning for GSK's approval of dutasteride for hair loss in Japan and South Korea but not the US, with alternatives such as finasteride, minoxidil and RU58841 mentioned.

community Topical Valproic acid/sodium valproate — has anyone tried this?

in Question 2 upvotes 4 years ago

The conversation is about using valproic acid, an anti-seizure medication, as a topical treatment to promote hair growth. The original poster is seeking personal experiences from those who have tried this method.

community At what point do you just drop all meds when its obvious that they don't work?

in Finasteride/Dutasteride 15 upvotes 9 months ago

The user has been on finasteride for over four years without noticeable results and recently added dutasteride and RU58841, but continues to experience hair loss. They are considering stopping all medications due to lack of effectiveness and side effects like extremely dry eyes from dutasteride.

community (26M) My 3 months progress on hair loss treatment. Extremely happy with the results. I have included so many details about my stack, my experience during the treatment, progress pictures, and everything I did during this time period.

in Progress Pictures 27 upvotes 1 year ago

A user's 3-month progress report on their treatment of hair loss using a stack of finasteride, dutasteride, and minoxidil, with additional supplements, diet and workout routine, and before-and-after photos.

community Wtf have we been doing for the last 30 years

in Treatment 525 upvotes 4 days ago

Hair loss treatments like finasteride, minoxidil, and dutasteride work but have side effects. A permanent cure is still not available due to the complexity of hair loss and limited investment.

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