34 citations
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June 2020 in “British journal of dermatology/British journal of dermatology, Supplement” In this study, researchers observed that follicular damage and stem cell loss in frontal fibrosing alopecia may be mediated by immune attacks at the bulge region, suggesting potential for JAK/STAT-targeting treatments to prevent progression.
April 2019 in “Journal of Investigative Dermatology” Targeting immune pathways like JAK/STAT may help treat frontal fibrosing alopecia.
35 citations
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February 2023 in “Biomolecules” This review explores the role of Granzyme B in autoimmune skin diseases and highlights its potential as a therapeutic target due to its involvement in impaired barrier function and inflammation.
52 citations
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March 2010 in “British Journal of Dermatology” This study demonstrated the expression of type 1 interferon-related proteins in inflammatory lesions of alopecia areata, showing a distinct distribution pattern compared to cicatricial alopecia.
127 citations
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January 2000 in “Journal of Investigative Dermatology” This study found that pro-inflammatory cytokines and apoptotic mechanisms, specifically involving granzyme B and Fas pathways, are associated with chronic alopecia areata, indicating their potential role in the disease's persistence.