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research DNA Methylation Dynamics During Esophageal Epithelial Regeneration Following Repair with Acellular Silk Fibroin Grafts in Rat

January 2023 in “Advanced Biology”

This study observed that DNA methylation dynamics, including global hypermethylation and site-specific changes, influenced gene expression associated with immune activation and PI3K-Akt signaling during esophageal tissue regeneration with acellular grafts.

research Topical Spironolactone in the Treatment of Ocular Graft-Versus-Host Disease

2 citations , September 2023 in “Curēus”

This study reported that topical spironolactone improved lid margin vascularity, corneal fluorescein staining, and disease severity scores in patients with ocular graft-versus-host disease, suggesting a potential therapeutic role by enhancing corneal lipid production with minimal adverse effects.

research Scaffolds for epithelial and hair follicle regeneration

1 citations , January 2019 in “Elsevier eBooks”

This chapter reviews the use of electrospun matrices in creating tissue-engineered skin substitutes and reports no new clinical results; it emphasizes the need for a cell-friendly microenvironment.

research Induction of Hard Keratin Expression in Non-Nail-Matrical Keratinocytes by Nail-Matrical Fibroblasts through Epithelial-Mesenchymal Interactions

25 citations , January 2003 in “Plastic & Reconstructive Surgery”

This study indicates that nail-matrical fibroblasts can induce hard keratin expression in non-nail-matrical keratinocytes, suggesting potential for using non-nail-matrical epidermal grafts to treat nail injuries.

research Effect of Cultured Dermal Substitute Composed of Collagen Sponge Seeded with Fibroblasts in Simultaneous Skin Graft Overlay

1 citations , March 2001 in “JOURNAL OF THE KYORIN MEDICAL SOCIETY”

In this study, a collagen sponge with isogenic fibroblasts did not enhance skin graft survival or wound healing in rats, but it did promote re-epithelization, potentially inducing epithelial inclusion cysts.

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community Hair cloning breakthrough, this might just be the big one ?

418 upvotes 6 months ago

Japanese scientists discovered ABM cells, enabling successful human hair follicle cloning, potentially curing hair loss. The treatment may be available in Japan by 2028, but it will be expensive and require travel.

community Quote from Pelage (PP-405) Spokesperson...

122 upvotes 11 months ago

Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

community Got my Oleic fatty acid they used in Korean study. Fuck you mice!

247 upvotes 7 months ago

Oleic acid and microneedling are being explored for hair regrowth, but results are mixed. Addressing DHT and fibrosis is crucial, with treatments like finasteride, minoxidil, and scalp massage also discussed.

community Researchers working on ways to regenerate lost hair from stem cells identified a recipe for normal hair regeneration in the lab. “A method for cyclical regeneration of hair follicles from hair follicle stem cells and will help make hair follicle regeneration therapy a reality in the near future.”

263 upvotes 5 years ago

Hair loss treatments like finasteride, minoxidil, and hair transplants have side effects and limitations. There is hope for future advancements in stem cell therapy and hair follicle regeneration, though skepticism about their effectiveness and timeline persists.

community 4960 grafts - HT result 7 months after

6 upvotes 4 days ago

A user shared their progress 7 months after a 4960 graft hair transplant, using dutasteride mesotherapy and oral minoxidil to stabilize hair loss. They are satisfied with the results so far and plan a second hair transplant in February 2027.

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