202 citations
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January 1989 in “Journal of Clinical Investigation” This study indicates that insulin changes sex hormone levels in insulin-resistant women with polycystic ovary syndrome without affecting gonadotropin release, challenging the idea that hyperinsulinemia directly causes hyperandrogenism in PCO.
1 citations
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January 2020 in “Bioscience Reports” This study found that prolonged use of finasteride in women led to altered levels of sex steroids, DNA damage, and increased menstrual bleeding, suggesting adverse health effects without clear benefits for androgenetic alopecia treatment.
3 citations
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May 2023 in “Endocrine Abstracts” This study identified three subgroups of women with PCOS with distinct androgen profiles, finding that the subgroup with adrenal-derived androgen excess had the highest insulin resistance and rates of hirsutism and hair loss.
20 citations
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March 1975 in “Clinics in Endocrinology and Metabolism” 2 citations
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November 2012 in “InTech eBooks” The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.