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GlossaryGonadotropin-Releasing Hormone Agonists (GnRHa)

medications that initially boost, then suppress, sex hormone production

Gonadotropin-Releasing Hormone Agonists (GnRH agonists) are medications that mimic the natural hormone GnRH, which regulates the release of other hormones like luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. Initially, they increase the production of these hormones, but with continuous use, they suppress their release, leading to reduced levels of sex hormones such as testosterone and estrogen. This makes them useful in treating hormone-sensitive conditions like prostate cancer, endometriosis, and certain types of breast cancer.

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Gonadotrophin-Releasing Hormone Agonist Therapy for Hirsutism Is as Effective as High Dose Cyproterone Acetate but Results in a Longer Remission

research Gonadotrophin-Releasing Hormone Agonist Therapy for Hirsutism Is as Effective as High Dose Cyproterone Acetate but Results in a Longer Remission

49 citations, April 1997 in “Human reproduction”

Hormone therapy for excessive hair growth is as good with GnRHa as with high-dose CPA, but GnRHa has longer-lasting results.

research Ovarian Hyperthecosis Coexisting with an Incidental Adrenal Lesion: Challenges in the Diagnostic Approach

June 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)”

Using GnRHa agonists helps diagnose and treat ovarian hyperthecosis when surgery isn't possible.

research Clinical Management of Youth with Gender Dysphoria in Vancouver

116 citations, December 2013 in “The Journal of Pediatrics”

Most youth with gender dysphoria received hormones, had minor complications, and showed a decrease in suicide attempts after treatment.

Physical Changes, Laboratory Parameters, and Bone Mineral Density During Testosterone Treatment in Adolescents with Gender Dysphoria

research Physical Changes, Laboratory Parameters, and Bone Mineral Density During Testosterone Treatment in Adolescents with Gender Dysphoria

71 citations, August 2019 in “The journal of sexual medicine”

Testosterone treatment effectively causes male physical development in transgender male adolescents but may lead to side effects like acne, higher BMI and blood pressure, lower good cholesterol, and decreased bone density.

The Effect of Gonadotropin-Releasing Hormone Analog Treatment in Precocious Puberty on Polycystic Ovarian Syndrome Prevalence in Adulthood

research The Effect of Gonadotropin-Releasing Hormone Analog Treatment in Precocious Puberty on Polycystic Ovarian Syndrome Prevalence in Adulthood

January 2024 in “Frontiers in endocrinology”

Treating early puberty with hormone therapy may increase the risk of polycystic ovary syndrome in adults.

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community 35 MtF | 16 Months | Minoxidil + Dutasteride + Microneedling + Exosomes. Note that since I'm early in my transition (and I was coming from a bald state), I still have short hair. Very few MtF progress pictures here, I figure this might help some of you.

in Transgender 125 upvotes 11 months ago

A 35-year-old transitioning female (MtF) shared her hair regrowth journey using Minoxidil, Dutasteride, Microneedling, and Exosomes, starting from a bald state. Commenters discussed the impressive results, skin care routine, and the effects of estrogen on hair and skin.

community 4 months after adding topical finasteride + melatonin, and switching from dermaroller to dr. Pen

in Treatment 225 upvotes 2 years ago

A user's experience using topical finasteride and melatonin to regrow hair, as well as their use of dermaroller versus dr. Pen for microneedling. People discussed the benefits of oral minoxidil and questioned if melatonin could help with hair regrowth.

community Insane MTF recovery 18 months blocking androgens

in Progress Pictures 145 upvotes 1 year ago

Hair loss recovery using estrogen and anti-androgen treatment for 18 months showed significant improvement. However, results vary and alternative treatments like RU58841 and Dutasteride may work without systemic feminization.

community New study shows that microneedling is an ineffective hair loss treatment

in Research/Science 1 year ago

The effectiveness of microneedling as a hair loss treatment, with evidence from studies and anecdotal accounts from other users. It is suggested that combining microneedling with minoxidil or finasteride may be more effective than using microneedling alone, although some people have had success using only microneedling.

community My Testosterone is less than 1/3rd In 7 Months since I took Finasteride!

in Finasteride/Dutasteride 113 upvotes 1 year ago

A user experienced a significant drop in testosterone levels after taking finasteride, leading to side effects like low libido and muscle mass loss. Despite its effectiveness for hair, the user decided to stop finasteride due to its impact on hormones, preferring to be bald.

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