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Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase

research Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase

5 citations, July 2021 in “Endocrinology, diabetes & metabolism”

Glioblastoma cells can make androgens, which might help the tumor grow.

research LGR5 Is a Marker of Poor Prognosis in Glioblastoma and Is Required for Survival of Brain Cancer Stem-Like Cells

82 citations, July 2012 in “Brain pathology”

High LGR5 levels in glioblastoma indicate poor prognosis and are essential for cancer stem cell survival.

research Targeting Evasion of Immune Pathways in Glioblastoma

15 citations, April 2017 in “Cell Stem Cell”

Some brain cancer cells avoid immune system detection, and certain treatments could target this to slow their growth; also, certain fat cell precursors help regenerate hair and skin after injury.

research Allopregnanolone Alters the Gene Expression Profile of Human Glioblastoma Cells

9 citations, March 2018 in “International journal of molecular sciences”

Allopregnanolone changes gene expression in glioblastoma cells.

research Antioxidant and Antiproliferative Activity of Finasteride Against Glioblastoma Cells

1 citations, September 2021 in “Pharmaceutics”

High-dose finasteride may help treat glioblastoma but needs localized delivery for effectiveness.

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community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 46 upvotes 6 months ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.