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research Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

380 citations , March 2000 in “Proceedings of the National Academy of Sciences”

This study demonstrates that mice with ectopic expression of the human GLI-1 gene in their skin developed tumors resembling human basal cell carcinoma, suggesting that GLI-1 is central to tumor development without additional p53 or Ha ras mutations.

research Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

333 citations , March 2000 in “Proceedings of the National Academy of Sciences”

In this study, researchers established that increased expression of the human GLI-1 gene in mouse skin leads to the development of tumors that closely resemble human basal cell carcinomas, without requiring additional mutations in the p53 or Ha ras genes.

Expression Patterns of Gli-1, Pleckstrin Homology-Like Domain, Family A, Member 1, Transforming Growth Factor-β1/β2, and p63 in Sebaceous and Follicular Tumors

research Expression Patterns of Gli-1, Pleckstrin Homology-Like Domain, Family A, Member 1, Transforming Growth Factor-β1/β2, and p63 in Sebaceous and Follicular Tumors

8 citations , January 2014 in “Annals of Dermatology”

This study found that TGF-β1 expression in follicular tumors correlates with differentiation degree and suggests its potential role alongside p63 in differentiating between sebaceous and follicular tumors.

research GLI2 Is Expressed in Normal Human Epidermis and BCC and Induces GLI1 Expression by Binding to its Promoter

171 citations , June 2004 in “Journal of Investigative Dermatology”

GLI2 activates GLI1, promoting skin tumor growth and hair development.

research Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis

6 citations , December 2019 in “Frontiers in genetics”

In this study, animal model observations suggested that GLI1 expression may reduce cSCC initiation but is not involved in the tumor's aggressiveness.

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learn Hair Transplant

What are the risks and side effects of a hair transplant? Common risks include swelling, redness, infection, scarring, and temporary hair loss.

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community Progressi in 9 mesi, da luglio 2025 a marzo 2026

in Progress Pictures 153 upvotes 6 months ago

The user shared their 9-month hair regrowth progress using topical Minoxidil 5%, finasteride 0.05%, retinoic acid 0.01%, dermastamping, ketoconazole shampoo, and supplements like biotin. They experienced some hair density improvement but minimal change in the hairline, with initial side effects from finasteride that resolved after dosage adjustment.

community Attention Guys, I highly recommend everyone to add this to your daily routine

in Microneedling 268 upvotes 1 year ago

Adding a daily scalp massage with an acupressure device before applying minoxidil can enhance its effects by improving blood circulation, with no side effects. Users are advised to continue microneedling weekly and consider using a derma stamp to avoid scarring.

community Short Peptides for Hair Loss: anyone tried any of these?

14 upvotes 5 months ago

Various peptides are discussed for treating male pattern baldness, with some available for topical use like GHK-Cu and Ac-KGHK, while others remain in research stages. Users are interested in experiences and sourcing these treatments.

community Qualcuno è riuscito a mantenere i capelli con la terapia del prof Marliani (dutasteride topica) ?

in Finasteride/Dutasteride 1 upvotes 1 year ago

The conversation discusses hair loss treatments, specifically topical dutasteride, minoxidil, and finasteride. Users share experiences and opinions on the effectiveness and side effects of these treatments.

community High estrogen on finasteride, thoughts?

37 upvotes 3 weeks ago

A 29-year-old male has been using finasteride for hair regrowth but is experiencing side effects like low libido and emotional changes, possibly due to high estrogen levels. Suggestions include weight loss, consulting an endocrinologist, switching to topical treatments, or trying dutasteride.

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research Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

research Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

research Expression Patterns of Gli-1, Pleckstrin Homology-Like Domain, Family A, Member 1, Transforming Growth Factor-β1/β2, and p63 in Sebaceous and Follicular Tumors

research GLI2 Is Expressed in Normal Human Epidermis and BCC and Induces GLI1 Expression by Binding to its Promoter

research Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis

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learn Hair Transplant

Community Join

community Progressi in 9 mesi, da luglio 2025 a marzo 2026

community Attention Guys, I highly recommend everyone to add this to your daily routine

community Short Peptides for Hair Loss: anyone tried any of these?

community Qualcuno è riuscito a mantenere i capelli con la terapia del prof Marliani (dutasteride topica) ?

community High estrogen on finasteride, thoughts?

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Jaimie Glick, MD

Kelly Grattagliano