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research Keloid pathogenesis and fibroproliferative properties are dependent on stem cells regulated by the HEDGEHOG-GLI1 pathway

May 2023 in “Research Square (Research Square)”

This study observed that the Hedgehog-GLI1 signaling pathway is upregulated in keloid patient–derived stem cells, and inhibiting this pathway reduced keloid characteristics in both mice and ex vivo tissue cultures, suggesting potential therapeutic targets for keloid treatment.

research Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells

396 citations , May 2011 in “Cell stem cell”

This study found that Shh from neurons signals to Gli1-expressing cells in the hair follicle, cultivating a niche where these bulge cells can potentially transform into epidermal stem cells in wound healing.

research Epithelial stem cells and implications for wound repair

156 citations , October 2012 in “Seminars in Cell & Developmental Biology”

This study found that hair follicle stem cells initially contribute to wound re-epithelialization, but long-lasting epidermal cells are primarily derived from a stem cell population in the isthmus portion of hair follicles.

research Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin

62 citations , November 2009 in “Aging Cell”

Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.

research Tooth, hair and claw: Comparing epithelial stem cell niches of ectodermal appendages

14 citations , February 2014 in “Experimental Cell Research”

This review examines the role of stem cells and their niches in continuously growing ectodermal organs like teeth, hair, and claws, providing insights from mouse models without presenting new research findings.

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learn Grape stem cells

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learn Stem Cell Factor

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community Stem-cell hair transplants! 20k lab grown grafts from one single graft

50 upvotes 2 years ago

Stem-cell hair transplants could potentially create thousands of grafts from a single donor graft, offering a solution for hair loss with DHT-resistant hair. Companies like Stemson Therapeutics and OrganTech are working on this technology, which may become available in the future, possibly reducing the cost and making it widely accessible.

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