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This study found that Alpinetin, applied topically in C57BL/6J mice, promoted hair regeneration by activating hair follicle stem cells through Wnt signaling, extending the anagen phase and increasing hair shaft length, with no cytotoxicity observed in keratinocytes and fibroblasts.

This study found that Shh from neurons signals to Gli1-expressing cells in the hair follicle, cultivating a niche where these bulge cells can potentially transform into epidermal stem cells in wound healing.

Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.

In this study, azelaic acid was found to enhance UVB protection in bulge cells and, when combined with minoxidil, may promote hair growth through increased Sonic hedgehog protein expression in hair follicles.

This review examines the role of stem cells and their niches in continuously growing ectodermal organs like teeth, hair, and claws, providing insights from mouse models without presenting new research findings.