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GlossaryKLF4 (GKLF)

transcription factor regulating cell growth and differentiation

KLF4, or Kruppel-like factor 4, is a protein that plays a crucial role in regulating cell growth, differentiation, and maintaining stem cell pluripotency. It is involved in various biological processes, including skin and hair follicle development, and has been studied for its potential implications in cancer and regenerative medicine.

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research The Tissue-Dependent Keratin 19 Gene Transcription Is Regulated by GKLF/KLF4 and Sp1

119 citations , September 2000 in “Journal of Biological Chemistry”

GKLF/KLF4 and Sp1 control Keratin 19 gene activity, influencing cancer-related changes.

Function of KLF4 in Stem Cell Biology

research Function of KLF4 in Stem Cell Biology

5 citations , August 2013 in “InTech eBooks”

KLF4 is important for maintaining stem cells and has potential in cancer treatment and wound healing.

Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and After Transplantation

research Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and After Transplantation

120 citations , August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Cytokeratin 19 and cytokeratin 15 are key markers for monitoring the quality and self-renewing potential of engineered skin.

Expression of Kruppel-Like Factor KLF4 in Mouse Hair Follicle Stem Cells Contributes to Cutaneous Wound Healing

research Expression of Kruppel-Like Factor KLF4 in Mouse Hair Follicle Stem Cells Contributes to Cutaneous Wound Healing

23 citations , June 2012 in “PLOS ONE”

KLF4 is important for maintaining skin stem cells and helps heal wounds.

A Genomic Approach to Susceptibility and Pathogenesis Leads to Identifying Potential Novel Therapeutic Targets in Androgenetic Alopecia

research A Genomic Approach to Susceptibility and Pathogenesis Leads to Identifying Potential Novel Therapeutic Targets in Androgenetic Alopecia

13 citations , March 2017 in “Genomics”

Genomic approach finds new possible treatments for hair loss.

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