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Medications Affecting the Insulin-Like Growth Factor 1/Growth Hormone Axis, Including Teprotumumab, Somatostatin Analogs, and Anti-Calcitonin Gene-Related Peptide Monoclonal Antibodies, Are Associated With Elevated Reporting Odds of Alopecia in Women: A Pharmacovigilance Study

research Medications affecting the insulin-like growth factor 1/growth hormone axis, including teprotumumab, somatostatin analogs, and anti-calcitonin gene-related peptide monoclonal antibodies, are associated with elevated reporting odds of alopecia in women: A pharmacovigilance study

April 2023 in “Journal of The American Academy of Dermatology”

This study investigated the association between hair loss and medications affecting the GH/IGF-1 pathway, using the FDA Adverse Event Reporting System to analyze reporting odds ratios of alopecia.

research Human Hair Follicles Operate a Functional Peripheral Equivalent of the Hypothalamic-Pituitary-Somatotropic Axis Ex Vivo

4 citations , December 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

This article discusses the role of human scalp hair follicles in neurohormone production and their model potential for studying neuroendocrine signaling, reporting no experimental results.

Neuroendocrinology of Human Scalp Hair Follicles: Growth Hormone-Releasing Hormone Stimulates Hair Growth and Controls a Fully Functional Intrafollicular Hypothalamic-Pituitary-Somatotropic Signaling Axis

research 562 Neuroendocrinology of human scalp hair follicles: Growth hormone-releasing hormone (GHRH) stimulates hair growth and controls a fully functional intrafollicular hypothalamic-pituitary-somatotropic (HPS) signaling axis

November 2022 in “Journal of Investigative Dermatology”

This study found that human scalp hair follicles produce neurohormones and responded to GHRH stimulation by prolonging hair growth, suggesting a functional peripheral HPS neuroendocrine signaling axis in the skin.

research The pediatric origins of polycystic ovary syndrome

January 2001 in “Cambridge University Press eBooks”

This article discusses polycystic ovary syndrome (PCOS), its symptoms, and links to insulin resistance and type 2 diabetes, but reports no new research findings; the authors emphasize recognition of features in youth.

The Effects of Estrogens on Linear Bone Growth

research The effects of oestrogens on linear bone growth

11 citations , July 2001 in “APMIS. Acta pathologica, microbiologica et immunologica Scandinavica./APMIS”

This review discusses the role of oestrogens in stimulating linear bone growth and pubertal changes in both boys and girls, highlighting their influence on the growth hormone-insulin-like growth factor axis; it reports no new clinical results.

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community Increasing GH and IGF-1 for Increased Growth/Reduced Hair Loss?

4 upvotes 2 years ago

Increasing IGF-1 may help hair growth, but it could also increase hair loss in people with high testosterone. Treatments discussed include l-arginine, glutamine, vanadium, Deer Antler Velvet, ATP, Cocarboxylase, l-carnitine, and Mk677.

community Best, possible, or experimental growth agonists that AREN'T MINOXIDIL.

4 upvotes 5 years ago

Various hair growth treatments were discussed, including microneedling, bimatoprost, setipiprant, stemoxydine, PGE2, CB-03-01, WNT Beta-Catenin upregulators, KY19382, topical estrogen, IGF-1, GH, MK-677, oral castor oil, fisetin, resveratrol, cetrizine, and lactic acid. Users shared experiences and sources for these treatments, with some expressing interest in topical solutions and others noting the lack of FDA approval or scientific evidence for certain options.

community IGFBP‐rP1 is a potential therapeutic target in androgenic alopecia

in Research/Science 13 upvotes 1 year ago

IGFBP‐rP1 shows potential for treating androgenic alopecia by influencing hair cycle transitions. Increasing IGF-1 levels may have similar effects to Minoxidil and 5-AR inhibitors in reducing hair loss.

community GH peptides + KLOW blend saved my hair. before and after pics.

833 upvotes 5 months ago

Using finasteride and peptides, including GHK-Cu, improved hair thickness and regrowth. The user also used a KLOW blend and CJC/IPA for better sleep and recovery.

community Anyone here in the 0% like me?

44 upvotes 2 years ago

The user has tried topical minoxidil, oral minoxidil, finasteride, RU58841, and dermapen for over a year without seeing hair regrowth and has now switched to dutasteride, planning to continue until summer. Some responses suggest that no further hair loss could be considered progress, question the visibility of hair loss, and recommend trying vitamin D.

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