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research Challenges Associated With the Identification of Germline Variants on Myeloid Malignancy Genomic Profiling—A Singaporean Experience

1 citations, October 2023 in “Frontiers in Oncology”

Genomic profiling for myeloid cancers can find important inherited mutations, but it's challenging when these mutations aren't related to the patient's symptoms.

research Coinheritance of BRCA2 and CYLD Germline Pathogenic Variants Associated with Targetable Metastatic Malignant Cylindroma

June 2023 in “British Journal of Dermatology”

Coinheritance of BRCA2 and CYLD genes may lead to new treatment options for certain cancers.

research A Monoallelic Two-Hit Mechanism in PLCD1 Explains the Genetic Pathogenesis of Hereditary Trichilemmal Cyst Formation

21 citations, October 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

A specific gene change plus an additional mutation in the same gene cause hereditary trichilemmal cysts.

research GWAS Identifies Three Susceptibility Loci for Trichilemmal Cysts

September 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

Three genes linked to the development of trichilemmal cysts were found.

research Genetic Variants in AR and SHBG and Resistance to Hormonal Castration in Prostate Cancer

6 citations, February 2013 in “Medical Oncology”

Certain genetic variants increase the risk of resistance to hormone therapy in prostate cancer patients.

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community Please stop looking for a natural way to stop your hairloss

in Chat 247 upvotes 2 years ago

There is no natural way to stop hair loss; pharmaceuticals like minoxidil, finasteride, and RU58841 are the only effective treatments. Some users report success with minoxidil and microneedling, while others discuss the side effects of finasteride.

community What should we lookout for in the near future for hairloss?

in Research/Science 17 upvotes 1 year ago

The user is using finasteride and minoxidil for hair loss but is looking for new treatments. Pyrilutamide and GT20029 are potential future treatments, with Pyrilutamide expected next year and GT20029 possibly by 2027.