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research Characterization of X-Linked SNP Genotypic Variation in Globally Distributed Human Populations

31 citations, January 2010 in “GenomeBiology.com (London. Print)”

The research concluded that selection significantly shaped the genetic variation of the X chromosome, with certain regions affected by past selective events.

research Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell Regeneration

21 citations, June 2016 in “PloS one”

Zebrafish need MYC and FGF to regenerate inner ear hair cells.

research The Hair Follicle as an Estrogen Target and Source

159 citations, July 2006 in “Endocrine Reviews”

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

research Reversal of the Hair Loss Phenotype by Modulating the Estradiol-ANGPT2 Axis in the Mouse Model of Female Pattern Hair Loss

5 citations, April 2018 in “Journal of Dermatological Science”

Adjusting estradiol-ANGPT2 levels can promote hair growth in female pattern hair loss.

research Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases

87 citations, May 2012 in “PLOS Genetics”

Six new genetic regions linked to early hair loss also connect to Parkinson's disease and prostate cancer, possibly leading to new treatments.

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community M18 Is it smart to start with minox only?

in General 126 upvotes 4 months ago

An 18-year-old is considering starting minoxidil for hair loss due to a receding hairline but is hesitant about using finasteride due to age and lack of health insurance. A suggestion was made to use topical finasteride and minoxidil, along with lifestyle changes like exercise and cold showers.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 2 years ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community Is it sufficient to block scalp DHT topically, or is it also necessary to reduce serum DHT? (My Question is Elaborated Below)

in Research/Science 17 upvotes 3 weeks ago

Topical finasteride can be as effective as oral finasteride for hair regrowth with fewer systemic side effects, but precise dosing is essential. Combining oral dutasteride with topical finasteride is not recommended due to dutasteride's stronger inhibition.

community We Need A Solution For The Inflammatory Response related To AGA

in Research/Science 16 upvotes 7 months ago

The conversation is about finding a solution for scalp inflammation related to AGA, with the user expressing frustration that Minoxidil and Finasteride do not address inflammation. The user has researched glucocorticoids and topical NSAIDs for reducing inflammation and seeks advice from specialists.

community How is it possible for someone to be a non responder to ORAL minoxidil?

in Minoxidil 66 upvotes 11 months ago

Some individuals do not respond to oral minoxidil for hair loss, despite it generally working by improving blood flow to hair follicles. Factors like metabolism, drug interactions, and individual variations in the drug's activation may influence its effectiveness.

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