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      Scarring Hair Follicle Destruction Is Driven by the Collapse of EGFR-Protected JAK-STAT1-Sensitive Stem Cell Immune Privilege

      research Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege

      October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”
      This study demonstrated that disrupting EGFR signaling in mice leads to immune sensitivity compromising the hair follicle's protective environment, but JAK1/2 inhibition can restore this immune privilege and stimulate hair growth, suggesting a potential therapy for scarring hair loss diseases like cicatricial alopecia.
      Etiopathogenesis of Alopecia Areata

      research Etiopathogenesis of Alopecia Areata

      2 citations , February 2014 in “Hair therapy & transplantation”
      This article reviews the autoimmune mechanism and potential environmental triggers of alopecia areata, focusing on cytokines, but does not provide new research findings.
      The Pathogenesis of Alopecia Areata

      research THE PATHOGENESIS OF ALOPECIA AREATA

      89 citations , October 1996 in “Dermatologic Clinics”
      This review discusses androgenetic alopecia and alopecia areata through a systems biology lens, emphasizing the role of multi-omics data integration to explore molecular mechanisms and potential therapeutic strategies, but offers no new clinical results.

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