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research Mimicking Hair Disorders by Genetic Manipulation of Organ-Cultured Human Hair Follicles

5 citations , September 2012 in “Journal of Investigative Dermatology”

This study found that knocking down P-cadherin expression in cultured human hair follicles recreates the hair abnormalities seen in patients with hypotrichosis with juvenile macular dystrophy.

research A new tool for conditional gene manipulation in a subset of keratin‐expressing epithelia

4 citations , July 2012 in “Genesis”

This study reported that a Megsin-Cre transgene enables genetic manipulation primarily in skin, forestomach, and esophagus tissues, offering a new tool for studying development and diseases in these areas.

research Skin grafting for the treatment of chronic leg ulcers – a systematic review in evidence‐based medicine

56 citations , March 2016 in “International Wound Journal”

This review concludes that autologous split-thickness skin grafting remains the gold standard for safety and efficacy in treating chronic leg ulcers, with greater success in venous ulcers.

research 606 Connecting signaling dynamics with cell fates in live mice

April 2021 in “Journal of Investigative Dermatology”

In this study, researchers observed that different ERK signal activation dynamics during hair follicle regeneration are linked to cell fate specification and are affected by distinct upstream signaling pathways.

research Functional enhancement strategies for immunomodulation of mesenchymal stem cells and their therapeutic application

53 citations , September 2020 in “Stem Cell Research & Therapy”

This review discusses strategies to enhance mesenchymal stem cell therapy effectiveness but reports no new clinical results; it highlights the need for improved consistency and efficacy in MSC-based treatments.

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community We are manipulating our hormones, surely it's prudent to track bloodwork ?

in Finasteride/Dutasteride 64 upvotes 2 years ago

The conversation discusses whether individuals using hair loss treatments like Dutasteride (Dut) or Finasteride (Fin) should regularly check their hormone levels through bloodwork. Some argue it's important to monitor the effects of these medications on hormone levels, while others believe it's unnecessary if there are no side effects, citing cost and practicality concerns.

community What Determines Sulfotransferase Enzyme Levels In The Body?

in Minoxidil 7 upvotes 1 year ago

Some people have low sulfotransferase enzyme levels, affecting their response to minoxidil. Lifestyle factors, genetics, and diet, like MSM intake, might influence these enzyme levels.

community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

373 upvotes 6 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

community Where do you think the cure will come from?

61 upvotes 1 month ago

The conversation discusses potential future cures for hair loss, including hair cloning, gene editing, and AI, with current treatments like hair transplants, minoxidil, and finasteride mentioned. Opinions vary on where a cure might originate, with some suggesting countries like China and South Korea.

community Evolution theory: AGA is your body trying to reduce the risk of prostate cancer by exposing your scalp to more UV

in Research/Science 9 months ago

Androgenic alopecia (AGA) might have evolved to reduce prostate cancer risk by increasing UV exposure to the scalp, but this theory is debated. Treatments like minoxidil and finasteride are used for AGA, though the exact causes and evolutionary reasons for hair loss are unclear.

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learn Vitamin B1

Thinning hair over time? It might not just be genetics: lack of B1 and B2 could be silently working against you. There is no verified human trial showing that B1 or B2 deficiency causes thinning hair or that correcting it regrows hair; a 2019 review concludes the role of micronutrients in hair loss is real but unclear and still needs controlled trials.

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