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research A homozygous missense mutation in the fibroblast growth factor 5 gene is associated with the long-hair trait in Angora rabbits

5 citations , June 2023 in “BMC genomics”

This study found that a specific genetic mutation in the Fgf5 gene may contribute to the long-hair trait in Angora rabbits by reducing the binding capacity of the FGF5 protein.

research Genetic basis of skin appendage development

111 citations , January 2007 in “Seminars in cell & developmental biology”

This article reviews the similarities in early development processes of hair follicles, teeth, and mammary glands and reports no new experimental findings.

research The Basic Science of Hair Biology

29 citations , September 2012 in “Dermatologic Clinics”

This article reviews the causal mechanisms of hair follicle disorders, focusing on inflammation, genetics, environment, and hormones, but it reports no new clinical results.

research Male-pattern hair loss: Comprehensive identification of the associated genes as a basis for understanding pathophysiology

April 2023 in “Medizinische Genetik”

This review discusses the current status of genetic research on male-pattern hair loss and reports no new findings, outlining significant achievements and future challenges in understanding its biology and treatment.

research Characterization of hairless (Hr) and FGF5genes provides insights into the molecular basis of hair loss in cetaceans

50 citations , February 2013 in “BMC evolutionary biology”

This study found that the Hr gene loss and positive selection for the FGF5 gene in cetaceans likely contributed to hair loss as these animals adapted to aquatic environments.

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Community Join

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community Whats up with all the dutasteride destroying hair posts

in Finasteride/Dutasteride 64 upvotes 3 years ago

User Basic_Football999 discusses concerns about negative dutasteride experiences. Replies suggest dutasteride is effective, but some users may have issues with dosing frequency or genetic factors affecting results.

community Sunlight: Does it Stimulate Hair Growth or Hair Loss?

in Research/Science 64 upvotes 2 years ago

The conversation discusses whether sunlight exposure affects hair growth or loss, with mixed anecdotes and theories but no clear consensus. Some suggest moderate sunlight can benefit hair by providing vitamin D, while others doubt its effectiveness compared to treatments like Minoxidil or finasteride.

community The new growth in hair loss research: With increasing evidence of its impact on mental health, scientists are pushing forward with breakthroughs on balding. Later this year, scientists will launch one of the first ever clinical trials with hair follicles grown entirely from stem cells.

324 upvotes 7 years ago

Hair loss impacts mental health, with treatments like Minoxidil, finasteride, and stem cell transplants discussed. There is hope for future breakthroughs, but current treatments are limited, and awareness is lacking.

community How much do you guys think diet and sleep affects results?

34 upvotes 3 years ago

The conversation discusses whether lifestyle factors like diet and sleep affect hair growth in people with reversible hair loss. Some believe these factors, along with treatments like minoxidil, finasteride, and RU58841, can improve hair health, while others argue hair loss is mostly determined by genetics and DHT sensitivity.

community How do you think Shah Rukh Khan maintains his full head of hair at 60?

453 upvotes 9 months ago

Shah Rukh Khan's hair at 60 is attributed to genetics, with speculation about using finasteride, minoxidil, or hair transplants. Some believe it's due to good genes, while others think he might use treatments or have had hair procedures.

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Learn

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learn Folic acid

How does folic acid support hair follicle health and growth at a cellular level? Folate is required for the DNA synthesis that fast-dividing hair matrix cells depend on, and severe deficiency causes anemia—but no published trial has given folic acid to people with hair loss and measured the result, so a growth effect is a mechanism, not a finding.

learn Osteopontin

A signalling protein that stimulated hair growth in mouse studies (Wang et al., Nature 2023). An osteopontin-derived peptide suppressed human hair growth in lab tissue (Alam et al., 2020). No osteopontin treatment is approved.

learn Stem Cell Factor

What is stem cell factor and why is it used in hair growth treatments? Stem cell factor is a signalling protein linked to hair colour in lab and mouse studies; it is not a proven hair-loss treatment in people.

learn Platelet-Rich Plasma

What is platelet-derived growth factor beta polypeptide (PDGF-BB), and does it stimulate new hair growth? PDGF-BB is a growth factor that signals to dermal papilla cells and promotes blood-vessel formation; mouse studies report it can push follicles into the growth phase, and human evidence comes only indirectly from PRP trials. No PDGF product is approved for hair restoration and there is no published human trial of PDGF-BB on its own.

learn KY19382

How does KY19382 actually stimulate dormant hair follicles to grow again? In mouse and cell studies, KY19382 reactivated hair follicles via Wnt/β-catenin signalling; it has never been tested in humans.

learn SCUBE3

a signaling molecule from dermal papilla cells that activated hair growth in mice; not tested in people and not an approved treatment

learn Procyanidin

What is Procyanidin, and how does it encourage hair growth at the follicle level? In mouse cell and animal studies, procyanidin B-2 increased hair-cell growth. Small human trials, all run by the company that developed the ingredient, reported modest gains; it is not a proven or approved hair-loss treatment.

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Clinics

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Hair Loss Treatments
Basis | Medical AestheticsKelowna, BC · CA

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