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GlossaryPruritus (Generalized Pruritus)

uncomfortable skin sensation causing the urge to scratch

Pruritus, commonly known as itching, is an uncomfortable sensation on the skin that provokes the urge to scratch. It can be caused by a variety of factors, including dry skin, allergic reactions, infections, or systemic conditions like liver disease. In a clinical context, pruritus can be a symptom of underlying dermatological or systemic issues, and its management often requires addressing the root cause.

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research Generalized Pruritus in Primary Sclerosing Cholangitis: Implications of Histamine Release by Lysophosphatidic Acid

5 citations, June 2015 in “British Journal of Dermatology”

A certain medication improved severe itching in a boy with liver and bowel disease by reducing histamine levels, suggesting a new treatment target.

research Iron Deficiency Anemia Pruritus: A Review with Proposed Mechanisms of Action

March 2024 in “Skin”

Iron deficiency anemia can cause itching, which often improves with iron supplements.

research Epidermolysis Bullosa Simplex Caused by Distal Truncation of BPAG1-e: An Intermediate Generalized Phenotype with Prurigo Papules

14 citations, May 2017 in “Journal of Investigative Dermatology”

A rare gene mutation causes skin fragility and itching without affecting hair or nails.

research Skin Manifestations of Hypothyroidism: A Clinical Study

6 citations, January 2013 in “IOSR Journal of Dental and Medical Sciences”

Most people with hypothyroidism have skin problems like dry skin and hair loss.

research COVID-19 Pandemic and Teledermatology in Low-Income Regions

2 citations, September 2021

The COVID-19 pandemic increased the use of teledermatology to treat skin conditions in low-income areas, despite challenges like poor photo quality.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 8 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Is hair thinning or loss associated with pain?

in Research/Science 6 upvotes 2 years ago

Hair thinning/loss associated with burning scalp pain. Finasteride helped relieve "DHT itch" for one person.

community Verteporfin update - donor hair regeneration human trial

in Research/Science 22 upvotes 2 years ago

A human trial of verteporfin, a potential treatment for hair loss, with some users noting potential improvements in scarring and overall healing compared to control areas.

community If follicles became miniaturized and haven’t grown in 3 years, are they dead ?

in Chat 2 years ago

Hair loss and its potential treatments, such as minoxidil, finasteride, RU58841, dermarolling, and supplements. It discusses whether miniaturized follicles can be revived to grow again or must shed for new growth to appear.

community 5 months 1mg Fin 4 month 5% Min

in Progress Pictures 570 upvotes 1 month ago

A 27-year-old user shared their 5-month progress using 1mg finasteride daily and 5% minoxidil twice a day for hair loss, reporting improved hair growth despite initial shedding and experiencing only minor side effects like watery semen. They also use Nizoral shampoo, take a multivitamin, and plan to start microneedling if progress slows.

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