Search

for
Search:

Research

5 / 1000+ results

research Gain‐of‐function variants in the ODC1 gene cause a syndromic neurodevelopmental disorder associated with macrocephaly, alopecia, dysmorphic features, and neuroimaging abnormalities

28 citations , November 2018 in “American Journal of Medical Genetics Part A”

This report describes a neurometabolic disorder linked to gain-of-function variants in the ODC1 gene, characterized by developmental delay, ectodermal abnormalities, and notable facial and neuroimaging features.

research JAK1 gain-of-function variant causes alopecia areata, atopic dermatitis, and autoimmune thyroid disease

1 citations , October 2025 in “Journal of Allergy and Clinical Immunology”

A JAK1 variant causes hair loss, skin issues, and thyroid disease, but treatment with a specific inhibitor can help.

research Grey, curly and short-haired Swiss Holstein cattle show genetic traces of the Simmental breed

2 citations , September 2020 in “Schweizer Archiv für Tierheilkunde”

This study found that Swiss cattle exhibiting rat-tail syndrome are heterozygous for genetic variants linked to pigmentation and color dilution, likely due to Holstein introgression in the Simmental breed.

research Prediction of gain-of-function and loss-of-function mutations using Combined Annotation Dependent Depletion (CADD)

1 citations , September 2017

This study found that the combination of Stemoxydine® and Resveratrol improved hair density in women with Female Pattern Hair Loss.

research Novel insights into cardiocutaneous syndromes

May 2022

This thesis found that desmoplakin mutations in cardiocutaneous syndrome are linked to dose-dependent disease severity and identified mechanisms by which KLHL24 mutations cause cardiomyopathy, with rescue experiments successfully preventing this phenotype in patient-derived heart tissues.

View more "gain-of-function variant" in research →

Community Join

5 / 787 results

community Could male-pattern baldness have a secondary photobiological function? The Solar Window Hypothesis

11 upvotes 3 weeks ago

Male-pattern baldness might increase UVB exposure on the scalp, potentially affecting vitamin D and skeletal health. The hypothesis is debated, with some seeing it as a minor benefit in specific contexts.

community Creatine and finasteride (DHT blocker)

6 upvotes 5 years ago

Creatine may increase DHT and potentially accelerate hair loss, but experiences vary. Finasteride, minoxidil, and microneedling are suggested to manage hair loss effectively.

community People are misunderstanding PP405. 31% response at 8 weeks is better than you think

181 upvotes 1 year ago

PP405 shows promise as a hair loss treatment, with 31% experiencing increased hair density in a short trial. It may complement treatments like finasteride and minoxidil, but long-term effectiveness and safety need confirmation.

community I am horny as hell due to fin.

in Finasteride/Dutasteride 225 upvotes 2 years ago

Some individuals taking finasteride for hair loss report increased libido and frequent masturbation, with no immediate hair regrowth but darker hair appearance. A dermatologist explains that finasteride may raise testosterone levels temporarily, which could lead to increased sex drive in some people.

community If you're worried that you're beginning to develop gyno on fin...

32 upvotes 3 months ago

Finasteride can cause gynecomastia due to increased estrogen from reduced DHT conversion, which some users manage by losing weight and taking supplements like DIM and calcium D-glucarate. Users discuss various experiences with finasteride, dutasteride, and minoxidil, noting side effects and strategies to mitigate them, including switching medications and considering surgery.

View more "gain-of-function variant" in community →

Learn

1 / 801 results

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

View more "gain-of-function variant" in learn →

Experts

— no results

Try a deeper search in experts →

Clinics

— no results

Try a deeper search in clinics →