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Author Response: Touch Receptor End-Organ Innervation and Function Require Sensory Neuron Expression of the Transcription Factor Meis2

research Author Response: Touch Receptor End-Organ Innervation and Function Require Sensory Neuron Expression of the Transcription Factor Meis2

February 2024

The transcription factor Meis2 is essential for touch sensation and proper nerve development in touch receptors.

research Sex Differences in the Effect of Finasteride on Acute Ethanol Withdrawal Severity in C57BL/6J and DBA/2J Mice

34 citations , May 2007 in “Neuroscience”

Finasteride reduces alcohol withdrawal severity in male mice but increases it in female mice.

research GABAA Receptor Modulation by Neurosteroids in Models of Temporal Lobe Epilepsies

40 citations , December 2012 in “Epilepsia”

Neurosteroids change how GABA_A receptors work in the brain, which could be important for treating temporal lobe epilepsy.

research Finasteride Blocks the Reduction in Ictal Activity Produced by Exogenous Estrous Cyclicity

65 citations , October 2008 in “Journal of Neuroendocrinology”

research Divergent Neuroactive Steroid Responses to Stress and Ethanol in Rat and Mouse Strains: Relevance for Human Studies

34 citations , April 2014 in “Psychopharmacology”

Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.

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Community Join

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community risks with finasteride and dutasteride

in Research/Science 138 upvotes 3 months ago

Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

community What to do if fin is still not working after 2.5 years

in Finasteride/Dutasteride 22 upvotes 4 months ago

The user is experiencing increased hair loss despite using finasteride and oral minoxidil and is hesitant to switch to dutasteride due to side effects and family planning concerns. Alternatives suggested include dutasteride, microneedling, and addressing stress or nutrient deficiencies.

community Kintor’s KX-826 Pyrilutamide!!

in Research/Science 151 upvotes 4 years ago

KX-826 hair loss treatment completed trials with mild side effects. GT20029 may be ultimate cure, destroying androgen receptors causing baldness.

community 22M started fin/min/dermaroller again after stopping for almost 2 years (2months progress)

in Progress Pictures 35 upvotes 1 month ago

A 22-year-old resumed using finasteride, minoxidil, and a 0.5mm dermaroller after stopping for two years, experiencing positive results and improved mood. The discussion includes debates on the effects of finasteride on neurosteroids and the optimal dermaroller needle length for hair regrowth.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 1 year ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.